Synthesis, characterization and antioxidant, antibacterial activity Zn2+, Cu2+, Ni2+ and Co2+, complexes of ligand [2-(thiophen-2-yl)-1-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole]

Elaaraj, Ibtissam; Raouan, Safae Er; Nakkabi, Asmae; Es-Sounni, Bouchra; Koraichi, Ibnsouda; Moualij, N. El; Fahim, Mohammad

doi:10.1016/j.jics.2022.100404

Cited by 16 publications

(7 citation statements)

References 26 publications

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“…[14,34,[56][57][58][59] Furthermore, the antioxidant potency of imines derived from imidazo [1,2-a]pyridines surpasses that of aliphatic imines or imines derived from various other heterocyclic families, such as benzimidazoles, quinolines, coumarins, and vanillin. [4,6,[19][20][21][22]60,61] This observation emphasizes the electron-rich nature of the imidazopyridine ring, which contributes to the enhanced antioxidant effectiveness of the synthesized imines.…”

Section: Antioxidant Activitymentioning

confidence: 77%

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

Moutaouakil,

Roby

et al. 2024

ChemistrySelect

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This study presents the synthesis of a novel series of imine derivatives derived from imidazo[1,2‐a]pyridine as potential therapeutic agents. The imines were obtained by condensing 2‐(4‐bromophenyl)‐6‐chloroimidazo[1,2‐a]pyridine‐3‐carbaldehyde with primary amines, leading to high‐purity products that were characterized using various spectroscopic techniques. The compounds demonstrated promising in vitro antimicrobial activity against various bacteria, including Staphylococcus aureus and Escherichia coli, as well as fungi, such as Candida albicans, Saccharomyces cerevisiae, and Aspergillus brasiliensis. Furthermore, the antioxidant properties of the imine derivatives were evaluated using DPPH and ABTS techniques, and the IC50 values measured revealed their ability to scavenge free radicals. Overall, this study provides a valuable contribution to the field of pharmacology by synthesizing a new series of imine derivatives with significant potential as new therapeutic agents, exhibiting both antimicrobial and antioxidant properties.

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Section: Antioxidant Activitymentioning

confidence: 77%

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

Moutaouakil,

Roby

et al. 2024

ChemistrySelect

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“…This activity is due to their ability to disrupt the cell membrane or the electron transport chain of bacteria, leading to the production of reactive oxygen species (ROS) that can damage and ultimately kill the bacteria. A study conducted by Elaaraj and his colleagues [88] compared the antibacterial activity of the cobalt (II) complex of [2‐(thiophen‐2‐yl)‐1‐(thiophen‐2‐ylmethyl)‐1H‐benzo[d]imidazole] ligand to that of the copper (II) and zinc (II) complexes. The results indicated that cobalt (II) complexes had the best antibacterial activity against the strains Bacillus subtilis , Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli compared to the other metal complexes.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterisation, Hirshfeld Surface Analysis, Magnetic Susceptibility, DFT Calculations, pkCSM Profile, and Biological Activities of Novel Mono‐, Di‐, and Multinuclear Cobalt (II) Complexes

Khaoua,

Mouffouk,

Benbellat

et al. 2024

Eur J Inorg Chem

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This study explores the synthesis and diverse properties of newly synthesised water‐soluble cobalt (II) complexes (1‐3). Analysis of the complexes through various methods, including Hirshfeld surface analysis, reveals distinctive intermolecular interactions, particularly robust H‐bonding contributions to crystal packing. 2D fingerprint plots provide quantitative insights into supramolecular interactions, while TGA‐DSC analysis elucidates multi‐step decomposition processes, mainly involving organic moieties. FT‐IR and SCXRD confirm the structures of the complexes. Magnetic susceptibility measurements show paramagnetic behaviour in all complexes. FMO calculations expose HOMO‐LUMO gaps and charge transfer processes, with NBO analysis emphasizing the significance of chloride, nitrogen, and oxygen atoms in coordination. In addition, pkCSM profile was carried out. The biological properties of the complexes reveal potent antibacterial activity for 2 and 3 against Gram‐positive and Gram‐negative bacteria. Despite lower antibacterial efficacy compared to standard antibiotics, their water solubility suggests potential human pharmacological applications. In terms of anti‐inflammatory activity, all three complexes exhibit concentration‐dependent prevention of ovalbumin denaturation, with 2 being the most effective. Compound 3, despite having seven carboxyl groups, exhibits the weakest anti‐inflammatory effect, potentially attributed to complex formation obscuring these groups. Furthermore, all complexes display antioxidant activities; 1 and 2 are greater than BHT in the ferric thiocyanate assay.

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“…This finding for Ni-doped CuSe is in accordance with previous findings that Ni 2+ complexes show strong antibacterial potency against E. coli bacterial strains. 57,58 4.1.2. Minimal Inhibitory Concentration (MIC) Determination.…”

Section: Resultsmentioning

confidence: 99%

Pristine, Ni- and Zn-Doped CuSe Nanoparticles: An Antimicrobial, Antioxidant, and Cytotoxicity Study

Patel

Chaki

Giri

et al. 2023

ACS Appl. Bio Mater.

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The strategy of chemical coprecipitation is implemented to synthesize nanoparticles of pristine CuSe, 5 and 10% Nidoped CuSe, and 5 and 10% Zn-doped CuSe. All of the nanoparticles are found to be near stoichiometric by the evaluation of X-ray energy using electron dispersion spectra, and the elemental mapping shows uniform distribution. By X-ray diffraction examination, all of the nanoparticles are identified as being single-phase and having a hexagonal lattice structure. Field emission microscopy with electrons in both scanning and transmission modes affirmed the spherical configuration of the nanoparticles. The crystalline nature of the nanoparticles is confirmed by the presence of spot patterns observed in the selected area electron diffraction patterns. The observed d value matches well with the d value of the CuSe hexagonal (102) plane. Findings from dynamic light scattering reveal the size distribution of nanoparticles. The nanoparticle's stability is investigated by ζ potential measurements. Pristine and Ni-doped CuSe nanoparticles exhibit ζ potential values in the preliminary stability band of ±10 to ±30 mV, while Zn-doped nanoparticles feature moderate stability levels of ±30 to ±40 mV. The potent antimicrobial effects of synthesized nanoparticles are studied against Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Enterobacter aerogenes, and Escherichia coli bacteria. The 2,2-diphenyl-1-picrylhydrazyl scavenging test is used to investigate the nanoparticle's antioxidant activities. The results showed the highest activity for control (Vitamin C) with an IC 50 value of 43.6 μg/mL, while the lowest for Nidoped CuSe nanoparticles with an IC 50 value of 106.2 μg/mL. Brine shrimps are utilized for in vivo cytotoxicity evaluation of the synthesized nanoparticles, which demonstrates that 10% Ni-and 10% Zn-doped CuSe nanoparticles are more damaging on brine shrimp instead on other nanoparticles with a 100% mortality rate. The lung cancer cell line of human (A549) is used to investigate in vitro cytotoxicity. The results indicate that pristine CuSe nanoparticles are more effective in the context of cytotoxicity against the A549 cell lines, possessing an IC 50 of 488 μg/mL. The particulars of the outcomes are explained in depth.

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Synthesis, characterization and antioxidant, antibacterial activity Zn2+, Cu2+, Ni2+ and Co2+, complexes of ligand [2-(thiophen-2-yl)-1-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole]

Cited by 16 publications

References 26 publications

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

Synthesis and Evaluation of Promising Antibacterial, Antifungal, and Antioxidant Activities for New Imidazo[1,2‐A]Pyridine‐Derived Imines

Synthesis, Characterisation, Hirshfeld Surface Analysis, Magnetic Susceptibility, DFT Calculations, pkCSM Profile, and Biological Activities of Novel Mono‐, Di‐, and Multinuclear Cobalt (II) Complexes

Pristine, Ni- and Zn-Doped CuSe Nanoparticles: An Antimicrobial, Antioxidant, and Cytotoxicity Study

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