Synthesis, characterization and antioxidant activity copper–quercetin complex

Bukhari, S. Birjees; Memon, Shahabuddin; Mahroof-Tahir, Mohammad; Bhanger, M. I.

doi:10.1016/j.saa.2008.07.030

Cited by 277 publications

(201 citation statements)

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“…6 and 7 (additional spectra in the Electronic Supplementary Material). The assignment was done on the basis of the literature data [19][20][21]. In the spectral range of 3390-3250 cm -1 bands assigned to the stretching vibrations of the -OH groups appeared.…”

Section: Infrared and Raman Analysismentioning

confidence: 99%

“…For example, it was found that Al(III) could form two complexes of stoichiometry of Al(III)/quercetin 1:2 or 2:1 and the first site involved in the metal chelation was the 3-hydroxychromone and the second one was the 3 0 ,4 0 -dihydroxyl group [18]. The study of Bukhari et al [19,20] showed that Cu(II), Co(II) formed complexes with quercetin where the metal/ligand ratio was 2:1; the 3-hydroxychromone and the 3 0 ,4 0 -dihydroxyl groups were engaged in chelation. According to Torreggiani et al [21] quercetin chelates Cu(II) ions through the 3 0 ,4 0 -dihydroxyl groups (metal/ligand ratio 0.5:1), in the excess of metal ions, the C=O group was also involved in metal chelation and the stoichiometry of Cu(II)/quercetin was 2:1.…”

Section: Introductionmentioning

confidence: 99%

“…The studies relying on the synthesis of new derivatives of biologically important phenolic compounds are very important, because as a result the new compounds with the enhanced desirable biological properties, i.e., antimicrobial, antioxidant and anticancer [27,28], might be obtained. Many studies revealed that complexation with copper (II) or chromium (III) improves antioxidant properties of metal complexes comparing with the free ligand [19,29] or complexation with rare earth metals (III) increases the antitumor activity of ligand [30].…”

Section: Introductionmentioning

confidence: 99%

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Spectroscopic, thermogravimetric and biological studies of Na(I), Ni(II) and Zn(II) complexes of quercetin

Kalinowska

Świderski

Matejczyk

et al. 2016

J Therm Anal Calorim

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The Na(I), Zn(II) and Ni(II) complexes with quercetin have been synthesized. The composition of these compounds was established by means of elemental and thermogravimetric analyses. To study the molecular structure of synthesized compounds, many miscellaneous analytical methods, which complement one another, were used: infrared (FT-IR), Raman (FT-Raman) and electronic absorption UV/VIS spectroscopy. For studying the cytotoxic and genotoxic activity of synthesized compounds, bioreporter strain of Escherichia coli K-12 recA::gfpmut2 has been used.

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Section: Infrared and Raman Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spectroscopic, thermogravimetric and biological studies of Na(I), Ni(II) and Zn(II) complexes of quercetin

Kalinowska

Świderski

Matejczyk

et al. 2016

J Therm Anal Calorim

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“…Quercetin is a natural polyphenolic antioxidant, which is present in vegetables, fruits and juices. It is a strong antioxidant because it can chelate metal ions such as Pd(II) [4], Cu(II) [5,6], Co(II) [7], Al(III) [8], scavenge oxygen free radicals [9,10] and prevent the oxidation of low density lipoprotein (LDL) in vitro [11]. Oxidized LDL is hypothesized to be an intermediate in the formation of atherosclerotic plaques [12].…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric determination of quercetin in pharmaceutical dosage forms

Pavun

Đurđević

Jelikić-Stankov

et al. 2014

Maced. J. Chem. Chem. Eng.

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A simple, accurate and precise method based on the fluorescence properties of the aluminum(III)-quercetin complex, for the determination of quercetin, has been developed and validated. The complex has strong emission at pH 3.30,  em = 480 nm, with  ex = 420 nm. The linearity range of quercetin determination was 1.5-60.5 ng ml -1 with LOD 0.09 ng ml -1 and LOQ 0.27 ng ml -1. Recovery values in the range of 99.9-100.2% indicate a good accuracy of the method. The established method was applied for the determination of quercetin in capsules, with a recovery value of 98.3%, standard deviation of 0.22% and coefficient of variation of 0.09%.The reliability of the method was checked by the newly developed RP-HPLC/UV method for capsules with the direct determination of quercetin after separation. The good agreement between the two methods indicates the applicability of the proposed spectrofluorimetric method for quercetin determination in pharmaceutical dosage forms, with high reproducibility, and enables the direct and simple determination without its prior extraction from samples.The proposed spectrofluorimetric method has much better sensitivity and LOD and LOQ values that are about 1000 times lower than data reported in the literature.Keywords: quercetin; flavonoids; spectrofluorimetric determination; RP-HPLC; capsules СПЕКТРОФЛУОРОМЕТРИСКО ОПРЕДЕЛУВАЊЕ НА КВЕРЦЕТИН ВО ФАРМАЦЕВТСКИ ДОЗИРАНИ ФОРМИРазвиен и валидиран е едноставен, точен и прецизен метод за определување на кверцетин заснован на флуоресцентните својства на комплексот кверцетин-алуминиум(III). Комплексот покажува силна емисија при pH 3,30,  em = 480 nm и  ex = 420 nm. Линеарниот опсег за определување на кверцетин е 1,5-60,5 ng ml -1 со LOD 0,09 ng ml -1 и LOQ 0,27 ng ml -1. Вредностите на аналитичкиот принос од 99,9-100,2% покажуваат добра точност на методот. Воспоставениот метод е применет за определување на кверцетин во капсули со вредност на аналитичкиот принос од 98.3%, стандардна девијација од 0,22% и коефициент на варијација од 0,09%.Веродостојноста на методот е проверена со новововедениот RP-HPLC/UV метод за капсули со директно определување на кверцетин по негова сепарација. Доброто согласување на двата метода укажува на применливост на предложениот спектрофлуорометриски метод за опреде-лување на кверцетин во фармацевтски дозирани форми со висока репродуцибилност и овозможува директно и едноставно определување без претходна екстракција од примероците.Предложениот спектрофлуорометриски метод има многу подобра осетливост и вредностите LOD и LOQ се за околу 1000 пати пониски од оние дадени во литературата.

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“…By making contact them with inorganic semiconductors, i.e. Si, GaAs, GaN and so on, many electronic and optoelectronic devices, OLEDs [1][2][3][4], Schottky Barrier Diodes (SBD) [5][6][7], OFETs [8][9][10]have been fabricating for long years. OLEDs have been extensively studied because of a large number of touchscreen mobile phone and thin displays fabrications.…”

Section: Introductionmentioning

confidence: 99%