Synthesis, Characterization and Antimicrobial Studies of 3‐[(2‐Hydroxy‐quinolin‐3‐ylmethylene)‐amino]‐2‐phenyl‐3H‐quinazolin‐4‐one and its Metal(II) Complexes

Abstract

A new complexes of the type ML2 and M′L [where M=Cu(II), Co(II), and Ni(II) and M′= Zn(II), Cd(II) and Hg(II)]. L = 3-[(2-hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one, (HQMAPQ) Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HQMAPQ acts as doubly monodentate bridge for metal(II) ions and form mononuclear complexes. The complexes Ni(II), Co(II) and Cu(II) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal(II) complexes were screened for their antimicrobial activity.

Synthesis, characterization and antimicrobial activity of new cobalt (II), nickel (II) and copper (II) complexes with 2-(2-hydroxy-1, 2-diphenylethylideneamino) benzoic acid

“…The observed magnetic moment of Cu(II) complex is 1.73 B.M. and it indicates an octahedral geometry [29][30][31][32]. Thus the electronic spectral data and magnetic moment data support the octahedral geometry of the complexes.…”

“…The Co(II) complex shows a magnetic moment of 4.94 B.M., the spin free octahedral complex of Co(II) is reported to exhibit magnetic moment in the range of 4.46-5.53 B.M. [27][28][29][30]. Hence, the observed magnetic moment for the Co(II) complex under study indicates that it has an octahedral configuration.…”

“…The magnetic moment of octahedral Ni(II) complexes are reported to exhibit magnetic moment in the range of 2.80-3.40 B.M. [28][29][30][31] indicating spin orbital coupling contribution from 3 A 2g and higher 3 T 2g states. Hence, the observed magnetic moment for the Ni(II) complex suggests that it may have octahedral geometry.…”

Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes

“…e band observed at 300 nm (33333 cm − 1 ) assigned to be charge transfer, while the shoulder peak at 342 nm (29240 cm − 1 ) arise from distortion. e Cu(II) complex also shows a band at 445 nm (22472 cm − 1 ) attributed to 2 E g ⟶ 2 T 2g transition, so distorted octahedral geometry was suggested to the Cu(II) complex [28,36].…”

Synthesis and antimicrobial activity of novel quinazolinone–thiazolidine–quinoline compounds

“…Intermediate compound (I) (2-phenylbenzo[d]1,3-oxazin-4one) (Bogert and Coriner, 1909) and compound (II) (3-amino-2-phenyl-3-hydroquinazolin-4-one) were prepared by following literature procedures (Siddappa et al, 2008). Reaction conditions were non-homogeneous and the use of an excess amount of hydrazine hydrate did not afford desired results.…”