Synthesis, Characterization, and Antibacterial Activities of 1H-Imidazo [5, 6-f] [1,10] Phenanthroline-2(3H)-Thione and Its Ni(II) and Cu(II) Complexes

Abstract

As multidrug resistant pathogens are emerging, the search for novel potent drug candidates is ever going. Heterocycles are known by their broad spectrum of biological activities, so a search for a new drug from heterocycles can elevate the chance of success. e aim of this study was to obtain novel potent antimicrobial compounds. In line with this, 1H-imidazo [5, 6-f] [1,10] phenanthroline-2(3H)-thione and its complexes (Ni(II) and Cu(II)) were synthesized, characterized, and evaluated against bacterial strains. e compounds were characterized by elemental analyses (C, H, N, and S), FT-IR, 1 H-NMR, 13 C-NMR, AAS, UV-Vis spectra, and molar conductivity measurement. e results showed that the ligand is bidentate, and the molar conductivity measurement indicates that complexes are electrolytic. Electronic spectral study showed octahedral and distorted octahedral geometry for the Ni(II) and Cu(II) complex, respectively. e ligand and its complexes were screened against four bacterial strains using disk diffusion method. e result revealed that the Ni(II) complex showed more bioactivity than gentamicin against Staphylococcus aureus and Escherichia coli, while the Cu(II) complex is more active than the Ni(II) complex against Bacillus subtilis. Both Cu(II) and Ni(II) complexes exhibit higher antibacterial activities than the free ligand.

Synthesis, Characterisation and Antimicrobial Studies of Mixed Ligands Metal (Ii) Complexes of Sulfamethoxazole and N,n- Donors Heterocycles

“…Hence, the need to seek for an alternative combination for sulfamethoxazole which will also offer expanded spectrum of action against disease pathogens. Reported literatures have suggested that heterocycles and their derivatives have excellent broad spectrum of biological activities (Helio et al, 2006;Taghreed et al, 2015), so a search for a new drug from heterocycles is believed to support the chance of success (Tirkeso et al, 2019). Among the heterocycles, 1,10-Phenanthroline (phen) and 2,2′ bipyridine (bipy) have extended planar π systems and can be used in model compounds to copy the non covalent interactions in biological processes (Armani et al, 2007).…”