Synthesis, characterization, and antimicrobial evaluation of some novel anthracene heterocycles derivatives

Abstract

A series of novel heterocyclic compounds containing anthracene moiety was synthesized. Reaction of (11R,15S)‐9,10‐dihydro‐9,10‐[3,4]furanoanthracene‐12,14‐dione with 2‐cyanoacetohydrazide gave 2‐cyano‐pyrroloanthracen acetamide (1), which acts as an adaptable material for the synthesis of new heterocyclic compounds. The synthesized compounds were examined for their antimicrobial activity against Escherichia coli and Staphylococcus aureus via p‐iodonitrotetrazolium violet formazon assay. The results exhibited great activity against the tested strains with a minimum bactericidal concentration range from 0.636 to 3.8 mg/mL) and 0.159 to 3.6 mg/mL for E coli and S aureus, respectively. Interestingly, the highest activity was recorded for chromene derivative (6) against both strains.

Synthesis and Antimicrobial Efficacy of Some Novel Heterocyclic Acetyl Istain Derivatives

“…Isatin derivatives has a large significant as substrates in many chemical reactions due to its utilize for the synthesis of a great variety of heterocyclic compounds, in addition to using as a raw material for drug synthesis [5]. Recently, isatin derivatives have attracted strong interest in organic and medicinal chemistry due to their potent biological and pharmacological activities [6], where the heterocyclic compound of isatin derivatives can be used as antimicrobial and antiviral [7], antifungal [8], antitumor [9], anticancer [10], act as ant proliferative agents [11], antibacterial [12,13], antimalarial [14], and antipyretic properties [15]. Schiff bases are generated by the condensation of a primary amine with a carbonyl compound at variety conditions [16].…”