Abstract:A series of novel heterocyclic compounds containing N-acetyl isatin moiety were synthesized. Herein, reaction of Nacetyl isatin with water in the presence of a catalytic amount of glacial acetic acid, via a ring opening route, yielded 2-(2acetamidophenyl)-2-oxoacetic acid, which acts as an adjustable precursor with different heteroaryl amines such as aniline, 2amino pyridine, 5-amino-1,3,4-thiadiazole-2-thiol and phenylhydrazeine for the preparation of different Schiff bases. Furthermore, acetamide derivatives… Show more
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