Synthesis, characterization and antimicrobial activity of peanut skin extract-azo-compounds

Kyei, Sampson Kofi; Akaranta, Onyewuchi; Darko, Godfred

doi:10.1016/j.sciaf.2020.e00406

Cited by 32 publications

(36 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Escherichia coli bacteria displayed a high susceptibility to the ligand. The findings showed that the form of compensated compound groups, for example, the group (-N=N-and N-H), in the studied ligand [48][49][50], influence the degree of efficacy and the bacteria type influencing them. Fungi, on the other hand, indicated that the majority of the compound tested had moderate to weak active ingredients (inhibition zones ranged from 6 to 9 mm) [51].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Synthesis, spectral characterization, lethal dose (LD50) and acute toxicity studies of 1,4-Bis(imidazolylazo)benzene (BIAB)

Kyhoiesh

Al-Hussainawy

Waheeb

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

Section: Antimicrobial Activitymentioning

confidence: 99%

Synthesis, spectral characterization, lethal dose (LD50) and acute toxicity studies of 1,4-Bis(imidazolylazo)benzene (BIAB)

Kyhoiesh

Al-Hussainawy

Waheeb

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

“…Azo dyes are suitable candidates to achieve this objective since they have been shown to be an important class of antimicrobial agents with versatile applications [16,17]. It has been established that the inclusion of a suitable heterocyclic moiety increases the activity of the azo linkage [18].…”

Section: Original Research Articlementioning

confidence: 99%

Antimicrobial Activity and In silico ADME Prediction of Synthesised 8-hydroxyquinoline Azo Compounds against Some ESKAPE Human Pathogens and Mycobacterium smegmatis

Amengor

Gyan²,

Danquah³

et al. 2022

JPRI

View full text Add to dashboard Cite

Introduction: Antimicrobial resistance has increasingly been a global health concern over the past decades and that has necessitated the quest to increase the pool of antibiotics. Methods: Five (5) azo compounds were synthesised by diazotization and coupling procedures with yields of 60 – 92%. They were characterized by melting point determination, Ultra-Violet Visible, and Infra-red spectroscopy. High-throughput spot culture growth inhibition (HT-SPOTi) antimicrobial assay was used to evaluate the compounds. Computational studies was also employed to predict some pharmacokinetic properties of the azo compounds Results: From the in silico studies, none of the compounds violated Lipinski’s rule and therefore, have the potential to be developed into an oral drug. They also showed Total Polar Surface Area (TPSA) values < 140 A2 (74.91 – 100.98 A2) and percentage absorption of 74 – 83 %. They were placed in category III of acute oral drugs. From the high-throughput spot culture growth inhibition antimicrobial assay, all the compounds possessed inhibitory activity against the ESKAPE human pathogens and Mycobacterium smegmatis, with MICs range of 3.9 \(\geq\) 500 \(\mu g/mL\). Except for 4e which showed liver toxicity, all the compounds demonstrated mutagenic and hepatotoxic tendencies. The modulatory assay of the azo compounds revealed that 4c and 4e modulated the antimicrobial activity of ciprofloxacin against Pseudomonas aeruginosa and Staphylococcus aureus. 4c and 4e also modulated the antimicrobial activity of rifampicin against Mycobacterium smegmatis. Exploiting the ability of 4c and 4e to act by a mode of action revealed that they have biofilm formation inhibitory potential. Conclusion: Compounds 4c and 4e exhibited the best antimicrobial activity in terms of resistant modulation and biofilm inhibition against Pseudomonas aeruginosa, Staphylococcus aureus and Mycobacterium smegmatis.

show abstract

“…In addition, they have found many applications in different fields such as non-linear optics (Dudek et al, 2020), optical storage (Kovalchuk et al, 2020), photoluminescence (He et al, 2019), chemosensors (Akram et al, 2020) and magnetism (Nandi et al, 2021). They are used not only in physics but also in the biomedical and pharmacological fields as they can offer new therapeutic properties such as antiviral (Chhetri et al, 2021), antimicrobial (Kyei et al, 2020), anti-inflammatory and antioxidant (Unnisa et al, 2020). On the other hand, azo-naphthol derivatives form a widely studied class of azo compounds.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure and Hirshfeld surface analysis of 1-[(E)-2-(5-chloro-2-hydroxyphenyl)hydrazin-1-ylidene]naphthalen-2(1H)-one

Bougueria¹,

Chetioui²,

Bensegueni³

et al. 2021

Acta Cryst E

View full text Add to dashboard Cite

The title compound, C16H11ClN2O2, was obtained by diazotization of 2-amino-4-chlorophenol followed by a coupling reaction with β-naphthol. There are two molecules (A and B) in the asymmetric unit. The crystal structure features only one type of intermolecular interaction, that is strong hydrogen bonds involving the hydroxyl group. The naphthol and phenol fragments attached to the C=N—N— moiety exhibit an s-trans conformation. In addition, those fragments are almost coplanar, subtending a dihedral angle of 13.11 (2)° in molecule A and 10.35 (2)° in molecule B. A Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H...H (32.1%), C...H/H...C (23.1%), Cl...H/H...Cl (15.2%), O...H/H...O (12.8%) and C...C (9%) contacts.

show abstract

Synthesis, characterization and antimicrobial activity of peanut skin extract-azo-compounds

Cited by 32 publications

References 47 publications

Synthesis, spectral characterization, lethal dose (LD50) and acute toxicity studies of 1,4-Bis(imidazolylazo)benzene (BIAB)

Synthesis, spectral characterization, lethal dose (LD50) and acute toxicity studies of 1,4-Bis(imidazolylazo)benzene (BIAB)

Antimicrobial Activity and In silico ADME Prediction of Synthesised 8-hydroxyquinoline Azo Compounds against Some ESKAPE Human Pathogens and Mycobacterium smegmatis

Crystal structure and Hirshfeld surface analysis of 1-[(E)-2-(5-chloro-2-hydroxyphenyl)hydrazin-1-ylidene]naphthalen-2(1H)-one

Contact Info

Product

Resources

About