Synthesis, characterization, and antimicrobial activity of new benzoylthiourea ligands

Abstract

In this study, new benzoylthiourea derivatives, (E)-N-[(2-benzamidomethyleneamino)ethylcarbamothioyl]benzamide H3L′, N-(1-(3-benzoylthioureido)propan-2-ylcarbamothioyl)-benzamide H4L″, (E)-N-[4-(benzamidomethyleneamino)phenylcarbamothioyl]benzamide H3L‴, were synthesized. Structures of the compounds were identified by spectroscopic techniques. In addition, all synthesized compounds were evaluated for in vitro antibacterial and antifungal activity. Compound H3L‴ exhibited antibacterial activity.

Synthesis and Characterization of Novel Thiourea Derivatives and Their Nickel and Copper Complexes

“…FT-IR spectra were taken with KBr pellets between 4000 and 400 cm −1 . In the FT-IR spectra of the synthesized benzoylthiourea derivatives show sharp and strong absorption band at 3231, 3293, 3271, 3166, and 3159 cm −1 for HL 1 , HL 2 , HL 3 , HL 4 , and HL 5 attributed to the stretching vibration of N-H group, respectively [11,12,21,22,[24][25][26][27][28].…”

“…Some derivatives are biologically active, such as antifungal [6,7], antitumour [8][9][10], antiviral, antibacterial [11][12][13], pharmacological [14], herbicidal, and insecticidal properties [11][12][13]. In addition, some of the research groups have reported thermal behaviour [15][16][17][18] and the acidity constants [19] of ligands of some benzoylthiourea derivatives and their metal complexes [20][21][22][23][24][25][26][27][28][29][30].…”

Experimental and DFT Investigation on the Influence of Electron Donour/Acceptor on the Hydrogen Bonding Interactions of 1-(1,3-Benzothiazol-2-yl)-3-(R-benzoylthiourea)

“…The chemical shifts for all protons are collected in Table 3. The (N-H)2 chemical shift of was further downshifted compared to This observation is influenced by the presence of greater hydrogen bonding effect (Arslan et al 2006;Kurt et al 2009;Zhou et al 2005). …”

“…Benzoylthiourea contains N, O and S donor atoms that make coordination chemistry of this molecule more interesting as it can behave as a monodentate, bidentate or tridentate ligand (Kurt et al 2009). The presence of intramolecular and intermolecular hydrogen bonding interactions that influence their coordination chemistry with the main group and transition metal elements (Domìnguez et al 2002).…”

In vitro evaluation of anti-pathogenic surface coating nanofluid, obtained by combining Fe3O4/C12 nanostructures and 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides

“…The (E)- N -[4-(benzamidomethyleneamino)phenylcarbamothioyl]benzamide synthesized by Kurt et al exhibited in vitro antibacterial activity against B. subtilis [7]. …”