Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance

Abstract

Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. the results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the l1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the l2 ligand. the activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. the best result was obtained to l2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/ml). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/ml), except the l1-Cr that was not active against any tested microorganism.

Novel Metal Coordination Complexes Based on 4-Aminophenol: Spectroscopic Analysis and Antibacterial Test

“…In the complex compound prepared by Mishra et al [10], the N and O groups of the ligands bind to metal ions Co(II), Cu(II), Ni(II), Zn(II), and Cd(II). Herrera et al [11] synthesized a complex of Co(II), Ni(II), and Cr(III) with 2-thiozoline-2-thiol and showed better antibacterial activity. Al-Zaidi et al [12] synthesized Co(II) with 1-(4-(4(diethylamino)-2hydroxybenzylidene)amino)phenyl)ethanone oxime ligand and the results showed improved antibacterial properties compared to the ligand and its complex ion.…”