Synthesis, Characterization and Antimicrobial Activities of Silver Nanoparticles coated [1,3] Thiazin-4-One derivatives

Abstract

Heterocyclic compounds have been used extensively used in pharmaceutical research area due to their effective biological activities. Thiazine, a heterocyclic compound with four carbon atoms, one nitrogen and one sulfur atoms which have promising pharmacological activities that have attracted the attention of scientists and researchers. In this research [3-(4-Amino-phenyl)-2-(4-nitro-phenyl)-2,3-dihydro-benzo[e][1,3]thiazin-4-one [comp. (2)] was used as a synthone for the preparation of Schiff bases [comp.(3)-(7)]. The synthesis compounds were characterized by FT-IR, 1H NMR and spectrophotometric methods. Furthermore, silver nanoparticles was prepared by chemical reduction and characterized by X-Ray diffraction (XRD), infra-red spectrum (FTIR), atomic force microscope (AFM) and scanning electron microscope (SEM). The Ag NPs was used as a base nano metal for preparing Schiff bases-Ag NPs derivatives. The pure Ag NPs and Ag NPs functionalized Schiff bases nano compounds were used to check their effectiveness against four different types of bacterial (Staphylococcus aurous, Staphylococcus epidermidis, Escherichia coli and Klebsiella sp.) and one type of fungal (Candida albicans) by a serial dilution method.

Enhanced hydrogen storage capacity of graphene oxide through doping with copper ferrite nanoparticles

“…SEM and TEM are useful techniques used to identify the type of nano‐structure of the prepared compounds as well as to calculate the dimensions of the particles at the nanoscale 71‐73 …”

“…SEM and TEM are useful techniques used to identify the type of nano-structure of the prepared compounds as well as to calculate the dimensions of the particles at the nanoscale. [71][72][73] Figure 3A,B shows the TEM measurements of graphene oxide nanosheets prepared by the modified Hammer method. It is clear from the figures that the sheets appear in isolation, one from the other, as it is noted that some parts of the layers are stacked on the other as a result of surface attraction due to the forces between different molecules, and because of the presence of hydrogen bonds arising between the sheets due to the presence of oxygenic groups on the surface as a result of the oxidation process.…”

Synthesis of 6-Membered-Ring Fused Thiazine-Dicarboxylates and Thiazole-Pyrimidines via One-Pot Three-Component Reactions

“…In this work, we set out to investigate alternative rings to act as the third component substrate in these reactions and selected the acidic six-membered ring 2-amino-4H-1,3thiazin-4-one derivatives 9, with predicted pK a values in the range of −1.80 to −2.21. Thiazines are bioactive scaffolds with a wide range of pharmacological activities, such as antimicrobial [20,21], anti-inflammatory [22], anticancer [23], antitubercular [24] and antiviral [25] activities. Another aim of this work was the further investigation of the two-component reactions between various five-membered rings and DMAD to prepare compounds such as 8 and their analogues.…”

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

“…Many heterocyclic compounds are also used as drugs, including hypnotics, anticonvulsants, antitumors, antihistamines, antiseptics and antivirals. [1][2][3][4][5][6][7] Every year, many new drugs featuring heterocyclic compounds are used in pharmacology to treat many human diseases. These new drugs, which consist of heterocyclic compounds, can be used to treat various diseases as many are active as antibacterial, [8][9][10] antifungal, 11 antiviral, 12 anti-inflammatory, 13 and antitumor 14,15 agents as well as being effective in other disease states.…”