Synthesis, Characterization and Anticancer Activity of Novel N-(Sugar Pyranosyl) Thienopyrimidine 4-Amine Derivatives

Abstract

A novel N-(sugar pyranosyl) thienopyrimidine 4-amine derivatives were synthesized. These derivatives were identified on the basis of melting point range, Rf values, IR and 1 H NMR spectral analysis. The derivatives were screened for anticancer activity. The derivatives exhibited significant to moderate anticancer activity.

Anticancer Studies of Novel 2, 4-Disubstituted -1, 5 -Diphenyl -1h-Imidazole Derivatives

“…They have wide range of biological activities. They are well known anti inflammatory 3 antidepressant 4 , anticancer [5][6] , antitubercular 7 antiviral 7--8 , antihypertensive 9 anthelmintic 10 , antihistaminic 11 , In view of such report and in continuation to our work on the imidazole derivatives as anticancer agent.…”

The synthesis, transformations and biological activity of thieno[2,3-d]pyrimidine derivatives with the carboxylic groups as the substituents in the pyrimidine ring

“…Роботи в напрямку синтезу похідних тієно[2,3-d]піримідину на основі амінів Гевальда дозволяють широко варіювати замісники в тіофеновому ядрі, завдяки чому похідні тієно [2,3-d]піримідину із замісниками в положеннях 5 та 6 є активно досліджуваними і відомими протягом багатьох років [1][2][3][4][5][6][7][8][9][10][11][12]. Похідні тієно [2,3-d]піримідину з карбоксильними замісниками в піримідиновому ядрі є значно менш досліджені.…”

Pharmacological activities of some triazinopyrazolothieno pyrimidine derivatives

“…Pyrazolopyrimidine derivatives showed the most pronounced activity against Mycobacterium tuberculosis comparable to that of the first line anti-tubercular drug isoniazid (1). Pyrimidine compounds showed an indirect anti-angiogenic effect through suppression of the secretion of VEGF and TGF-b1 from prostate cancer cells (2) and have, among others, been evaluated as cGMP phosphodiesterase inhibitors, but also as kinase inhibitors and potential anti-cancer agents (3). Pyrimidine derivatives were also found to have anti-inflammatory activity in BALB/c mice with locally induced edema (4).…”