Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds

Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation

“…Nitrogen‐containing heterocyclic compounds, which are involved in an extraordinarily wide range of reaction types in vitro and in vivo, constitute many important structural units of marketed drugs. The clinical applications of these compounds include anti‐bacterial, anti‐viral, anti‐fungal, anti‐inflammatory, and anti‐tumour drugs …”

Recent advances on antimony(III/V) compounds with potential activity against tumor cells

“…19) were synthesized and characterized [34]. The NMR spectroscopy confirms the retention of the structures in solution.…”

S-NICS Investigation for Heterocyclic Anticancer Compounds

“…Currently, a number of drugs are used in the treatment 11 of the cancer, but most of them were produced controlled effect on the cancer cells. The usual applications of heterocycles are as vast as it is diverse and is not extensively 9 encompassed in the scope 10 of that study.…”

“…Many of heterocyclic compounds are known as anticancer drugs such as alkylating agents which have targeted cell DNA causing cell death. Heterocycles 1 structures are composed by atoms other than carbon, where the most times substituents are sulfur, oxygen 1 and nitrogen 1,2 .The model size of heterocycles ring, together with the substituent group of the core scaffold 2 , impact tightly on the chemical and physical properties 3 while among the clinical applications, heterocyclic compound has an active role as anti-bacterial 4,5 , anti-viral 6 , anti-fungal 7 , antiinflammatory 8 and anti-tumor drugs [9][10][11] .…”

“…Structure activities relationship was reduced 9 from biological results and will be used in further design 11 of new active compounds. Currently, a number of drugs are used in the treatment 11 of the cancer, but most of them were produced controlled effect on the cancer cells.…”