Synthesis, biological evaluation, and QSAR studies of organosilicon(IV) complexes derived from tridentate ONO Schiff bases of dehydroacetic acid and aromatic hydrazides

Synthesis, spectral analysis and in vitro cytotoxicity of diorganotin (IV) complexes derived from indole‐3‐butyric hydrazide

“…In the present work, hydrazide Schiff base ligands (1-4) were synthesized by the reaction of indole-3-butyric hydrazide with the salicylaldehyde and its derivatives in methanol solvent. Sixteen new diorganotin (IV) complexes (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were prepared by reaction of hydrazide Schiff base ligands with R 2 SnCl 2 in 1:1 molar ratio by adding triethylamine as base. The spectroscopic data describes the synthesized diorganotin (IV) complexes to have pentacoordinated geometry with the tridentate ligands (ONO).…”

“…Hydrazide Schiff bases and their diorganotin (IV) complexes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were screened for the antimicrobial activity against four bacterial strain Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and two fungal strains Aspergillus niger and Candida albicans. The experiments were performed in duplicate by serial dilution method using ciprofloxacin and fluconazole as positive standard and DMSO as negative standard for antibacterial and antifungal activity.…”

“…The organotin moiety is decisive for cytotoxicity, DNA cleavage, antimicrobial, anti-inflammatory, analgesic, antioxidant, antiHIV etc. [15][16][17][18][19][20] The ligand scaffolds also play a key role in the chemotherapy. Schiff base ligands having hydrazide groups are considered as "privileged ligands" and used widely due to their easy synthetic procedure, good solubility and their novel structural features.…”

Synthesis, Biological Activity and QSAR Studies of Organotin(IV) and Organosilicon(IV) Complexes

“…They are also reported to act as insecticidal, acaricidal, nematicidal and herbicidal agents. In addition, Schiff base organotin(IV) and organosilicon(IV) complexes were of great interest for structural reasons as they offer a great variety of molecular architectures, leading to diverged coordination modes . Among Schiff bases, the condensation products of pyron with amines or their derivatives act as very good complexing agents and their metal complexes are considered as convenient and versatile synthon in heterocyclic chemistry.…”

Unprecedented isolation of a dinuclear tin (II) complex stabilized by pyridine‐2,6‐dimethanol: structure, DFT and in vitro screening of cytotoxic properties

“…Tin complexes have witnessed vast range of applications in various biological and industrial fields . Such compounds possess fascinating medicinal importance like antiparasite agents, in horticulture as bactericidal, acraricidal and fungicidal medium, anti‐HIV and antitumor agents . The biological activity and specially the anticancer activity of tin compounds is governed by geometrical features, extent of hydrolysis of ligands and coordination number around central tin metal ion .…”