Synthesis, Biological Activity and QSAR Studies of Organotin(IV) and Organosilicon(IV) Complexes

Abstract

A panel of penta‐coordinated, neutral organotin(IV) and organosilicon(IV) complexes of newly designed Schiff bases: 4‐(2‐hydroxymethyl‐phenylimino)‐2‐methyl‐4H‐pyran‐3‐ol (H2L1) and 4‐(benzothiazol‐2‐ylimino)‐2‐methyl‐4H‐pyran‐3‐ol (HL2) were synthesized and characterized using elemental analysis, spectral studies (UV/Vis, IR, 1H, 13C, 29Si, 119Sn NMR and Fluorescence) and thermal technique. Spectral studies conferred that the Schiff base act as bi/tridentate and form the penta coordinated geometry with oxygen and nitrogen donor atom (NO/NOO). The compounds were screened for in vitro antimicrobial activity using twofold serial dilution method against Gram‐positive bacteria (Staphylococcus aureus, Bacillus cereus), Gram‐negative bacteria (Escherichia coli, Klebsiella pneumoniae) and fungi (Aspergillus niger, Candida albicans). The antimicrobial study exposed good activity with tri‐ and di‐phenyl derivatives exhibiting excellent biological activity. Compounds 5, 6, 10, 13, 14, 17 and 18 displayed better activity than the standard drugs. Quantitative structure activity relationship involves correlation of biological activity with the structural properties of the compounds using statistical means.

Synthesis, characterisation and biological activity of diorganotin compounds of (E)-N'-(5-nitro-2-hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide

“…An important class of organotin compounds are those derived from Schiff bases. These have received great attention owing to their structural diversity, thermal stability and wide range of possible biological applications [10][11][12]. Organotin compounds of Schiff bases have been proposed to possess mild to good anti-cancer [12][13][14][15][16][17], anti-microbial [11,14,[18][19][20][21][22], anti-leishmanial [23,24] and anti-inflammatory [20,25,26] potentials.…”

Synthesis, Spectroscopic, Biological Activity, Molecular Docking and Density Functional Theoretical Investigations of Novel Tellurium(IV) Schiff Base Complexes

“…Isatin (Indole-2,3-dione) and its derivatives are versatile heterocyclic compounds with a variety of antiviral, antimicrobial [19] and anticonvulsant activities. [10,[20][21][22] Schiff bases derived from Isatin have also been reported to possess important applications such as identification, detection and purification of carbonyl compounds.…”

Effect of ‐OMe Substituent on Salicylaldehyde Schiff Base to Influence the Zn2+ Sensitivity and the Cancer Cell Line Imaging

“…Henceforth, it is a great demand to develop the probe for selective, sensitive and rapid detection of zinc ions. Schiff bases with two or more donor centres of varying degree of hardness have good binding with metal ions . In this work, three new selective Zn 2+ sensors of salicylaldehyde Schiff bases are made to investigate the effect of substituents to improve the sensitivity of the detection process.…”

“…Schiff bases with two or more donor centres of varying degree of hardness have good binding with metal ions. [25][26] In this work, three new selective Zn 2 + sensors of salicylaldehyde Schiff bases are made to investigate the effect of substituents to improve the sensitivity of the detection process. The syntheses of sensors are accomplished in good yields and the structures of these sensors (1-3) are characterized by 1 H, 13 C NMR, mass spectroscopy and elemental analysis.…”