“…Metronidazole (2-methyl-5-nitro-1 H -imidazole-1-ethanol, MNZ), shown in Figure , is a 5-nitroimidazole derivative that exhibits great and selective activity against anaerobic bacteria (e.g., Staphylococcus aureus and Escherichia coli ) − and some protozoa (e.g., Entamoeba , Trichomonas , Trypanosoma , and Leishmania spp. ). − It has also been shown to have excellent antifungal properties . Unfortunately, over the years, its overuse has led to the development of MNZ-resistant microorganisms. − Among the various methods reported in the literature to overcome the resistance issue, complexation with transition metals has proven to be one of the strategies with the greatest potential to enhance the bioactivity of MNZ and protect it from degradation by gastric juice .…”