Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base

Abstract

BackgroundThe transition metal complexes formed from Schiff base is regarded as leading molecules in medicinal chemistry. Because of the preparative availability and diversity in the structure of central group, the transition metals are important in coordination chemistry. In the present work, we have designed and prepared Schiff base and its metal complexes (MC1–MC4) and screened them for antimicrobial, anticancer and corrosion inhibitory properties.MethodologyThe synthesized metal complexes were characterized by physicochemical and spectral investigation (UV, IR, 1H and 13C-NMR) and were further evaluated for their antimicrobial (tube dilution) and anticancer (SRB assay) activities. In addition, the corrosion inhibition potential was determined by electrochemical impedance spectroscopy (EIS) technique.Results and discussionAntimicrobial screening results found complexes (MC1–MC4) to exhibit less antibacterial activity against the tested bacterial species compared to ofloxacin while the complex MC1 exhibited greater antifungal activity than the fluconazole. The anticancer activity results found the synthesized Schiff base and its metal complexes to elicit poor cytotoxic activity than the standard drug (5-fluorouracil) against HCT116 cancer cell line. Metal complex MC2 showed more corrosion inhibition efficiency with high Rct values and low Cdl values.ConclusionFrom the results, we can conclude that complexes MC1 and MC2 may be used as potent antimicrobial and anticorrosion agents, respectively.

Synthesis and structures of divalent Co, Ni, Zn and Cd complexes of mixed dichalcogen and dipnictogen ligands with corrosion inhibition properties: experimental and computational studies

“…The observed higher inhibition efficiency for Ni follows the trend previously reported. 59,60 Furthermore, electrochemical parameters obtained from linear polarization measurements revealed that the studied complexes behaved as excellent corrosion inhibitors for mild steel in the studied acidic medium. The values of polarization resistance (R p ) which are obtained from the slope of current densitypotential graph for each studied complex ranged from 135.45 to 628.24 U cm 2 and were greater than the 42.28 U cm 2 of the uninhibited solution.…”

Schiff base metal complex as a potential therapeutic drug in medical science: A critical review

“…The bacteria were grown in double-strength nutrient broth and fungi in Sabouraud dextrose broth. Similarly, the cytotoxicity of the synthesized compounds was found below the efficiency of standard 5fluorouracil drugs [43]. Shaygan et al (2018) have made a new approach for the determination of the antibacterial activity of newly synthesized Co(II) metal complexes derived from the Schiff base (16 and 17) of terephthalaldehyde and ortho-aniline.…”

“…Based on the comparative study, the IC50 values of Co-complex of (14) were reported to be11.3±2.7µM, 17.8±3.1µM, and 19.8±4.8µM against A-431, HT-144, and SK-MEL-30 respectively. Kashyap, et al (2018) explored the antimicrobial and cytotoxic activity of newly synthesized metal complexes derived from the Schiff base of mhydroxybenzaldehyde and 4-amino antipyrine. The structure and binding of metals with the Schiff base ligand were confirmed by UV-Vis, FT-IR, NMR, and TGA spectrum analysis.…”

Preparation ,Spectral Characterization ,DFT and Antibacterial of New Azo Ligand Derived From 2-aminoanthracene-9,10-dione With Antipyrine Mixed ligand Complexes involving 1,10-phenanthroline ligand.

“…The Ni(II) complex also exhibits three weak absorption bands at (11235 cm -1 ) , (13440 cm -1 ) and (22727cm -1 ) assignable to 3 A2g(F)(ν1) → 3 T2g(F), 3 A2g(F) (ν2) → 3 T1g(F) , 3 A2g(F) (ν3) → 3 T1g(P) which are characteristic of octahedral geometry around Ni(II) ion . The Cu(II) complex depicts a broad band in the region (13560cm -1) to (17760 cm -1 ) with maximum at 15625 cm -1 assignable to 2 Eg → 2 T2g in its spectrum, the broadness of the band may be due to distorted octahedral geometry [3][4][5][6][7][8][9][10][11][12].…”

“…Azo compound derived from hemicyclic amines containing their metal complexes, particularly fused with anthrequinone have been drawing the interest of many studies due to their biological activities [3,4]. compounds show biological activities such as antifungal, antibacterial, antiinflammatory and anthelmintic [6], antitubercular [7], antiblood pressures, antiallergic, antiasthma [8] and anticancer [9]. The study of azo dyes of pyrazoline-2-one and pyran-2-one derivatives has been of much interest in recent years due to theirantibacterial, antiviral, anticancer, antifungal, antihelminthes and insecticidal activities [1].…”