Synthesis, Biological Activity and Computational Study of Some New Unsymmetrical Organotellurium Compounds Derived from 2-Amino-5-carboxyphenyl Mercury(II) Chloride

Al-Asadi, Rafid H.; Al-Masoudi, Wasfi A.; Abdual-Rassol, Khawla S.

doi:10.14233/ajchem.2016.19139

Cited by 16 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aromatic ring in REOC II and REOC III is 6.72 and 6.44 ppm, respectively [ 40 ]. After the reaction, a 5.77 ppm peak of the amino group in REOC II disappears [ 41 ], and a new peak of the methylene group is located at 4.26 ppm.…”

Section: Resultsmentioning

confidence: 99%

Effects of Ligands in Rare Earth Complex on Properties, Functions, and Intelligent Behaviors of Polyurea–Urethane Composites

et al. 2022

View full text Add to dashboard Cite

There is a need to create next-generation polymer composites having high property, unique function, and intelligent behaviors, such as shape memory effect (SME) and self-healing (SH) capability. Rare earth complexes can provide luminescence for polymers, and their dispersion is highly affected by ligand structures. Here, we created three different REOCs with different ligands before studying the effects of ligands on REOC dispersion in polyurea–urethane (PUU) with disulfide bonds in main chains. In addition, the effects of different REOCs on mechanical properties, luminescent functions, and intelligent behaviors of PUU composites were studied. The results showed that REOC I (Sm(TTA)3phen: TTA, thenoyltrifluoroacetone; phen, 1,10-phenanthroline) has incompatible ligands with the PUU matrix. REOC I and REOC III (Sm(BUBA)3phen: BUBA, 4-benzylurea-benzoic acid) with amine and urea groups facilitate their dispersion. It was REOC III that helped the maintenance of mechanical properties of PUU composites due to the good dispersion and the needle-like morphologies. Due to more organic ligands of REOC III, the fluorescence intensity of composite materials is reduced. The shape recovery ratio of the composite was not as good as that of pure PUU when a large amount of fillers was added. Besides, REOC I reduced the self-healing efficiency of PUU composites due to poor dispersion, and the other two REOCs increased the self-healing efficiency. The results showed that ligands in REOCs are important for their dispersion in the PUU matrix. The poor dispersion of REOC I is unbeneficial for mechanical properties and intelligent behavior. The high miscibility of REOC II (Sm(PABA)3phen: PABA, 4-aminobenzoic acid) decreases mechanical properties as well but ensures the good shape recovery ratio and self-healing efficiency. The mediate miscibility and needle-like morphology of REOC III are good for mechanical properties. The shape recovery ratio, however, was decreased.

show abstract

Section: Resultsmentioning

confidence: 99%

Effects of Ligands in Rare Earth Complex on Properties, Functions, and Intelligent Behaviors of Polyurea–Urethane Composites

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay, 17,18 was employed to test the in vitro cytotoxicity of the test compounds. The human breast cancer cell line (MCF7) was purchased from the National Cell Bank of Iran (Institute Pasteur, Iran).…”

Section: Evaluation Of Anti-cancer Activitymentioning

confidence: 99%

Synthesis, Anti-breast Cancer Activity, and Molecular Docking Studies of Thiourea Benzamide Derivatives and Their Complexes with Copper Ion

2023

TJNPR

View full text Add to dashboard Cite

IntroductionThioureas are a well-known class of versatile organic compounds that have been extensively synthesized and investigated for many years due to their ability to undergo structural modification. 1 These compounds have proven to be industrially important by having two reactive primary amine group units. Thiourea can therefore be used to create a wide range of useful biologically interesting chemical groups, leading to an essentially infinite number of structures with novel physicochemical features. These properties add to the understanding of thiourea chemicals. [2][3][4] Compounds containing carbonyl and thiocarbonyl groups occupy a necessary position among organic reagents as workable donor ligands for transition metal ions. 5-6 Among these thiourea derivatives are potentially very versatile ligands and can coordinate to a range of metal centers as neutral ligands, monoanions, or dianions. [6][7] A wide range of thiourea applications in industries, chemistry, medicine, and other fields may be facilitated by the oxygen, nitrogen, and sulphur donor atoms of thiourea and its derivatives.

show abstract

“…MTT assay [19] was employed to test in-vitro cytotoxicity of studied compounds. Human breast cancer (MCF-7 cell line) was obtained from National Cell Bank of Iran.…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Schiff Bases Ligands Derived from o-Phthalaldehyde and Their Metal Complexes with Cu2+ and Ni2+: Synthesis, Anti-Breast Cancer and Molecular Docking Study

Ahmed

Al-Asadi

2023

Trends Sci

View full text Add to dashboard Cite

The Schiff bases and their complexes have an observed biological efficacy, so in the current study it has been prepared, characterized and evaluated the biological activity of some Schiff bases and their metal complexes with copper and nickel and based on ortho-phathaldehyde as a primary compound. A new Schiff bases ligands and metal complexes {[Cu(L)n(H2O)2]Cl2.mH2O and [Ni(L)n].mH2O, where L=N',N'''-((1E,1'E)-1,2-phenylenebis(methanylylidene)) di(benzohydrazide) L1, N',N'''-((1E,1'E)-1,2-phenylenebis (methanylylidene)) di(isonicotinohydrazide) L2, 1,2-bis((E)-(2-(2,4,6-trichlorophenyl)hydrazono)methyl) benzene L3 ; n = 1, 2 ; m = 0, 1, 3/2, 5/2} have been synthesized and elucidated by mass, FT-IR, 13C and 1HNMR, molar conductivity, flame-atomic absorption, magnetic susceptibility, Powder-XRD and TG analysis. The results showed that the L1 and L2 ligands behave as a tetra-dentate donor and were associated with metal ions in a molar ratio of 1:1, while L3 ligand was bi-dentate donor and associated with metal ions in 1:2 molar ratio. In addition, the geometric shapes of the prepared complexes were tetrahedral and square planar for Ni2+ and Zn2+ complexes, and octahedral for Cu2+ complexes. The effect of cellular toxicity in the laboratory has been examined by MTT assay for all compounds against the MCF-7 cancer breast cell line and found to have low efficacy except [Cu(L3)2(H2O)2] Cl2.H2O (5). The copper complex's molecular docking has been performed with breast cancer proteins using the MOE program, and found to target ERα, CDK6 and EGFR proteins by binding to hydrogen bonds and pi-interactions. HIGHLIGHTS Synthesis new chemical compounds, which are some Schiff bases and their metal complexes with copper and nickel ions Characterization of chemical structure of synthesized compounds by mass, FT-IR, 13C and 1HNMR, molar conductivity, flame-atomic absorption, magnetic susceptibility, Powder-XRD and TG analysis Study the biological activity of synthesized compounds as anti-breast cancer Study of molecular docking of compounds that showed biological efficacy with proteins responsible for breast cancer cells GRAPHICAL ABSTRACT

show abstract

Synthesis, Biological Activity and Computational Study of Some New Unsymmetrical Organotellurium Compounds Derived from 2-Amino-5-carboxyphenyl Mercury(II) Chloride

Cited by 16 publications

References 0 publications

Effects of Ligands in Rare Earth Complex on Properties, Functions, and Intelligent Behaviors of Polyurea–Urethane Composites

Effects of Ligands in Rare Earth Complex on Properties, Functions, and Intelligent Behaviors of Polyurea–Urethane Composites

Synthesis, Anti-breast Cancer Activity, and Molecular Docking Studies of Thiourea Benzamide Derivatives and Their Complexes with Copper Ion

Schiff Bases Ligands Derived from o-Phthalaldehyde and Their Metal Complexes with Cu2+ and Ni2+: Synthesis, Anti-Breast Cancer and Molecular Docking Study

Contact Info

Product

Resources

About