Synthesis, biocompatibility and cell labeling of l-arginine-functional β-cyclodextrin-modified quantum dot probes

Zhao, Mei‐Xia; Xia, Qing; Feng, Xudong; Zhu, Xu‐Hui; Mao, Zong‐Wan; Ji, Liang‐Nian; Wang, Kui

doi:10.1016/j.biomaterials.2010.01.114

Cited by 61 publications

(27 citation statements)

References 37 publications

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“…4 A significant amount of effort has been expended on the improvement of the intracellular delivery and bioimaging of QDs with reduced toxicity through conjugation of QDs with various molecules including biomacromolecules, [5][6][7][8] biocompatible polymer molecules, 9 and peptides. 10 Recently, QDs have been incorporated into various drug delivery systems that can be used not only as molecular imaging agents but also for therapy application.…”

mentioning

confidence: 99%

New strategy of efficient inhibition of cancer cells by carborane carboxylic acid–CdTe nanocomposites

Shi

et al. 2012

Nanomedicine: Nanotechnology, Biology and Medicine

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mentioning

confidence: 99%

New strategy of efficient inhibition of cancer cells by carborane carboxylic acid–CdTe nanocomposites

Shi

et al. 2012

Nanomedicine: Nanotechnology, Biology and Medicine

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“…The surface modification of QDs with CDs has been shown to reduce cytotoxicity and enhance biocompatibility . This manipulation not only preserves the imaging capabilities of the nanocarrier but also potentially affords the nanocarrier additional therapeutic functionalities such as drug loading.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Quantum Dot Nanoparticles for Effective Differentiation and Long‐Term Tracking of Human Mesenchymal Stem Cells In Vitro and In Vivo

Lee

et al. 2016

Adv Healthcare Materials

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Human mesenchymal stem cells (hMSCs) hold great potential for regenerative medicine. Efficient induction of hMSC differentiation and better understanding of hMSCs behaviors in vitro and in vivo are essential to the clinical translation of stem cell therapy. Here a quantum dots (QDs)-based multifunctional nanoparticle (RGD-β-CD-QDs) is developed for effective enhancing differentiation and long-term tracking of hMSCs in vitro and in vivo. The RGD-β-CD-QDs are modified with β-cyclodextrin (β-CD) and Cys-Lys-Lys-Arg-Gly-Asp (CKKRGD) peptide on the surface. The β-CD can harbor hydrophobic osteogenic small molecule dexamethasone (Dex) and the RGD peptide not only facilitates the complexation of siRNA and delivers siRNA into hMSCs but also leads to cellular uptake of nanoparticles by RGD receptor. Co-delivery of Dex and siRNA by RGD-β-CD-QDs nanocarrier significantly expedites and enhances the osteogenesis differentiation of hMSCs in vitro and in vivo by combined effect of small molecule and RNAi. Furthermore, the RGD-β-CD-QDs can be labeled with hMSCs for a long-term tracking (3 weeks) in vivo to observe the behaviors of implanted hMSCs in animal level. These findings demonstrate that the RGD-β-CD-QDs nanocarrier provides a powerful tool to simultaneously enhance differentiation and long-term tracking of hMSCs in vitro and in vivo for regenerative medicine.

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“…Meanwhile, a polymer film (P-β-CD-L-Arg) was formed on the surface of the CNTs@GNRs/GCE through the combination of L-Arg with each other by intermolecular condensation between -NH 2 and -COOH (Liu et al, 1999;Zhao et al, 2010).…”

Section: Characterization Of P-β-cd-l-arg/cnts@gnrsmentioning

confidence: 99%

Highly sensitive and simultaneous electrochemical determination of 2-aminophenol and 4-aminophenol based on poly( l -arginine)-β-cyclodextrin/carbon nanotubes@graphene nanoribbons modified electrode

Zhu

et al. 2016

Biosensors and Bioelectronics

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Synthesis, biocompatibility and cell labeling of l-arginine-functional β-cyclodextrin-modified quantum dot probes

Cited by 61 publications

References 37 publications

New strategy of efficient inhibition of cancer cells by carborane carboxylic acid–CdTe nanocomposites

New strategy of efficient inhibition of cancer cells by carborane carboxylic acid–CdTe nanocomposites

Multifunctional Quantum Dot Nanoparticles for Effective Differentiation and Long‐Term Tracking of Human Mesenchymal Stem Cells In Vitro and In Vivo

Highly sensitive and simultaneous electrochemical determination of 2-aminophenol and 4-aminophenol based on poly( l -arginine)-β-cyclodextrin/carbon nanotubes@graphene nanoribbons modified electrode

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