New strategy of efficient inhibition of cancer cells by carborane carboxylic acid–CdTe nanocomposites

Wu, Chunhui; Shi, Lixin; Li, Qingning; Jiang, Hui; Selke, Matthias; Yan, Hong; Wang, Xuemei

doi:10.1016/j.nano.2011.10.011

Cited by 28 publications

(16 citation statements)

References 43 publications

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“…However, some of the cells incubated with the MTX nanoparticles (D) and MMCMs (C/M) (E/F) exhibited obvious orange patches of fragmented and condensed chromatin, nuclear fragmentation, or apoptotic bodies, all of which are characteristics of apoptotic programmed cell death. Therefore, the above observations demonstrated that MMCMs (C/M) could dramatically induce apoptosis of MG-63 cells [37], which was also supported by the results obtained from the effect of MMCMs (C/M) on MG-63 cell growth in vitro.…”

Section: The Effect Of Mmcms (C/m) On Mg-63 Cell Morphologysupporting

confidence: 81%

The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2

Chen

Ting-ting

Wang

et al. 2014

Sci. China Life Sci.

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The in vitro and in vivo anti-tumor efficacy of methotrexate-loaded Fe 3 O 4 -poly-L-lactide-poly(ethylene glycol)-poly-L-lactide magnetic composite microspheres (MTX-Fe 3 O 4 -PLLA-PEG-PLLA MCMs, MMCMs), which were produced by co-precipitation (C) and microencapsulation (M) in a supercritical process, was evaluated at various levels: cellular, molecular, and integrated. The results at the cellular level indicate that MMCMs (M) show a better anti-proliferation activity than raw MTX and could induce morphological changes of cells undergoing apoptosis. At the molecular level, MMCMs (M) lead to a significantly higher relative mRNA expression of bax/bcl-2 and caspase-3 than MMCMs (C) at 10 µg mL 1 (P<0.01); and the pro-caspase-3 protein expression measured by Western blot analysis also demonstrates that MMCMs (M) can effectively activate pro-caspase-3. At the integrated level, mice bearing a sarcoma-180 tumor are used; in vivo anti-tumor activity tests reveal that MMCMs (M) with magnetic induction display a much higher tumor suppression rate and lower toxicity than raw MTX. Pharmacokinetic studies show that MMCMs (M) with magnetic induction significantly increase the accumulation of MTX in the tumor tissue compared with the other treatments. These results suggest that the MMCMs (M) prepared by the SpEDS process have great potential to play a positive role in the magnetic targeted therapy field.

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Section: The Effect Of Mmcms (C/m) On Mg-63 Cell Morphologysupporting

confidence: 81%

The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2

Chen

Ting-ting

Wang

et al. 2014

Sci. China Life Sci.

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“…67 In an extension of this idea, the conjugation of o-carborane-1,2-dicarboxylic acid to green-emitting CdTe quantum dots (QDs) quenches their fluorescence intensity and induces a red shift in the emission peak, which improves the efficiency of inhibition of target cancer cells relative to that observed with CdTe QDs in the absence of carboranes. 69 69 …”

Section: Quantum Dotsmentioning

confidence: 99%

Carboranes in the chemist's toolbox

2015

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Once seldom encountered outside of a few laboratories, carboranes are now everywhere, playing a role in the development of a broad range of technologies encompassing organic synthesis, radionuclide handling, drug design, heat-resistant polymers, cancer therapy, nanomaterials, catalysis, metal-organic frameworks, molecular machines, batteries, electronic devices, and more. This perspective highlights selected examples in which the special attributes of carboranes and metallacarboranes are being exploited for targeted purposes in the laboratory and in the wider world.

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“…The group treated with diluted Rosup (50 mg/mL, supplied in the ROS assay kit; Beyotime Institute of Biotechnology, Nanjing, China) were applied as positive control following the manufacturers' protocols. 29 After 24 h treatment, the cells were washed with PBS for two times and further incubated with DCFH-DA in the dark for 20 min. Then the cells were washed with FBS-free RPMI 1640 medium for three times to remove excess DCFH-DA and collected after trypsinization.…”

mentioning

confidence: 99%

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Luo¹,

Liu²,

Cui³

et al. 2017

IJN

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Background The natural compound curcumin (Cur) can regulate growth inhibition and apoptosis in various cancer cell lines, although its clinical applications are restricted by extreme water insolubility and instability. To overcome these hurdles, we fabricated a Cur-coordinated reactive oxygen species (ROS)-responsive nanoparticle using the interaction between boronic acid and Cur. Materials and methods We synthesized a highly biocompatible 4-(hydroxymethyl) phenylboronic acid (HPBA)-modified poly(ethylene glycol) (PEG)-grafted poly(acrylic acid) polymer (PPH) and fabricated a Cur-coordinated ROS-responsive nanoparticle (denoted by PPHC) based on the interaction between boronic acid and Cur. The mean diameter of the Cur-coordinated PPHC nanoparticle was 163.8 nm and its zeta potential was −0.31 mV. The Cur-coordinated PPHC nanoparticle improved Cur stability in physiological environment and could timely release Cur in response to hydrogen peroxide (H 2 O 2 ). PPHC nanoparticles demonstrated potent antiproliferative effect in vitro in A549 cancer cells. Furthermore, the viability of cells treated with PPHC nanoparticles was significantly increased in the presence of N -acetyl-cysteine (NAC), which blocks Cur release through ROS inhibition. Simultaneously, the ROS level measured in A549 cells after incubation with PPHC nanoparticles exhibited an obvious downregulation, which further proved that ROS depression indeed influenced the therapeutic effect of Cur in PPHC nanoparticles. Moreover, pretreatment with phosphate-buffered saline (PBS) significantly impaired the cytotoxic effect of Cur in A549 cells in vitro while causing less damage to the activity of Cur in PPHC nanoparticle. Conclusion The Cur-coordinated nanoparticles developed in this study improved Cur stability, which could further release Cur in a ROS-dependent manner in cancer cells.

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New strategy of efficient inhibition of cancer cells by carborane carboxylic acid–CdTe nanocomposites

Cited by 28 publications

References 43 publications

The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2

The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2

Carboranes in the chemist's toolbox

Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

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