Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Luo, Cheng-Qiong; Liu, Xing; Cui, Pengfei; Qiao, Jian-Bin; He, Yujing; Chen, Baoan; Jin, Liang; Jiang, Hu‐Lin

doi:10.2147/ijn.s122678

Cited by 49 publications

(42 citation statements)

References 41 publications

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“…Uniform spherical particles were obtained with a particle size around 163.8 nm that in the presence of H 2 O 2 is able to release curcumin. Cellular studies demonstrated the efficient release of curcumin into A549 cells [103]. Delivery systems have been developed to overcome the low solubility and poor bioavailability of curcumin [103].…”

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

“…Cellular studies demonstrated the efficient release of curcumin into A549 cells [103]. Delivery systems have been developed to overcome the low solubility and poor bioavailability of curcumin [103]. Luo and co-workers designed curcumin-conjugated nanoparticles for delivery into A549 lung cancer cell line.…”

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

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Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

et al. 2018

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A very promising direction in the development of anticancer drugs is inhibiting the molecular pathways that keep cancer cells alive and able to metastasize. Copper and iron are two essential metals that play significant roles in the rapid proliferation of cancer cells and several chelators have been studied to suppress the bioavailability of these metals in the cells. This review discusses the major contributions that Cu and Fe play in the progression and spreading of cancer and evaluates select Cu and Fe chelators that demonstrate great promise as anticancer drugs. Efforts to improve the cellular delivery, efficacy, and tumor responsiveness of these chelators are also presented including a transmetallation strategy for dual targeting of Cu and Fe. To elucidate the effectiveness and specificity of Cu and Fe chelators for treating cancer, analytical tools are described for measuring Cu and Fe levels and for tracking the metals in cells, tissue, and the body.

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Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

Section: Efforts To Optimize Drug Delivery and Efficacy Of Cu Chelatomentioning

confidence: 99%

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

et al. 2018

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“…28,33,34 In other words, besides the hydrophobic region of PLGA being efficient in hydrophobic drug encapsulation, the hydration on the hydrophilic PEG corona can further prevent nanocarriers from aspecific protein adsorption and reticuloendothelial system clearance for prolonging blood circulation in vivo. [35][36][37][38][39] Therefore, PEGylated PLGA nanoparticles are advanced platforms to enhance targeted antitumor drug delivery.…”

Section: Chen Et Almentioning

confidence: 99%

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

Chen¹,

Wu²,

Luo³

et al. 2017

IJN

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Further specific target-ability development of biodegradable nanocarriers is extremely important to promote their security and efficiency in antitumor drug-delivery applications. In this study, a facilely prepared poly(lactic- co -glycolic acid) (PLGA)–polyethylene glycol (PEG)–folic acid (FA) copolymer was able to self-assemble into nanoparticles with favorable hydrodynamic diameters of around 100 nm and negative surface charge in aqueous solution, which was expected to enhance intracellular antitumor drug delivery by advanced dual tumor-target effects, ie, enhanced permeability and retention induced the passive target, and FA mediated the positive target. Fluorescence-activated cell-sorting and confocal laser-scanning microscopy results confirmed that doxorubicin (model drug) loaded into PLGA-PEG-FA nanoparticles was able to be delivered efficiently into tumor cells and accumulated at nuclei. In addition, all hemolysis, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, and zebrafish-development experiments demonstrated that PLGA-PEG-FA nanoparticles were biocompatible and secure for biomedical applications, even at high polymer concentration (0.1 mg/mL), both in vitro and in vivo. Therefore, PLGA-PEG-FA nanoparticles provide a feasible controlled-release platform for secure and efficient antitumor drug delivery.

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“…Recently, Chen et al reported the anti-metastatic effect of curcumin against EC cancer cells in vitro [2]. However, the clinical efficacy of curcumin is extremely limited because it has poor oral bioavailability [8], low water solubility, instability in gastrointestinal fluids and/or alkaline/higher pH conditions, and rapid systemic elimination [9].…”

Section: Introductionmentioning

confidence: 99%

“…Various strategies have been utilized to overcome the limitations of curcumin to enable its therapeutic application, such as complexation with biodegradable microspheres, hydrogels, and polymeric nanoparticles [9,10]. Among them, numerous studies have shown that the incorporation of curcumin into liposomes significantly increases its bioavailability [11,12].…”

Section: Introductionmentioning

confidence: 99%

Liposomal Curcumin Targeting Endometrial Cancer Through the NF-κB Pathway

Gong

Zhou

et al. 2018

Cell Physiol Biochem

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Background/Aims: Emerging evidence suggests that curcumin possesses chemopreventive properties against various cancers. However, its poor bioavailability limits its clinical application. In this study, we aimed to utilize encapsulation in liposomes (Lipo) as a strategy for the clinical administration of curcumin for endometrial carcinoma (EC). Methods: Curcumin was encapsulated in a liposomal delivery system to prepare a formulation of liposomal curcumin (LC). EC cell lines Ishikawa and HEC-1 were treated with the compound and cell proliferation was measured using MTT assay. Hoechst 33258 staining assay and flow cytometry were used to detect apoptosis of the cells. Wound healing and cell invasion assays were employed to monitor cell motility. Underlying target signaling, such as NF-κB, caspases, and MMPs, were further studied via qRT-PCR and western blot. Thereafter, a zebrafish model was used to assess the toxicity of LC. Finally, a zebrafish transplantation tumor model of EC was grown and treated with LC. Tumors were monitored and harvested to study the expression of NF-κB. Results: The formation of LC was successfully developed with excellent purity and physical properties. In vitro, LC resulted in dose-dependent inhibition of proliferation, induction of apoptosis, and suppression of Ishikawa and HEC-1 cell motility. LC treatment also suppressed the activation and/or expression of NF-κB, caspase-3, and MMP-9. No demonstrable toxicity was found in the zebrafish model and tumors were suppressed after treatment with LC. PCR analysis also showed down-regulated expression of NF-κB. Conclusions: LC was successfully prepared and played biological roles against EC probably through negative regulation of the NF-κB pathway in vitro and in vivo, which demonstrates its potential therapeutic effects in EC.

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Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Cited by 49 publications

References 41 publications

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

Liposomal Curcumin Targeting Endometrial Cancer Through the NF-κB Pathway

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Curcumin-coordinated nanoparticles with improved stability for reactive oxygen species-responsive drug delivery in lung cancer therapy

Cited by 49 publications

References 41 publications

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Iron and Copper Intracellular Chelation as an Anticancer Drug Strategy

Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)&ndash;polyethylene glycol&ndash;folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery

Liposomal Curcumin Targeting Endometrial Cancer Through the NF-κB Pathway

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Dual tumor-targeted poly(lactic-<em>co</em>-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery