Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

“…[ 4,5 ] The derivatives of quinoline and hydrazone and their complexes have been reported to demonstrate a widespread spectrum of biological properties, [ 6–8 ] such as antimicrobial, [ 9–11 ] antibacterial, [ 12–14 ] antifungal, [ 15,16 ] antiviral, [ 17 ] antiplatelet [ 18 ] antimalarial, [ 19 ] antitubercular, antimycobacterial, [ 20,21 ] anticancer, [ 21–24 ] antianalgesic, anticonvulsant, [ 25 ] and antileishmanial, [ 26,27 ] The hydrazones and their metal complexes also have anti‐uropathogenic, [ 28 ] anti‐arthritic, [ 29 ] antiproliferative, [ 30 ] and antioxidant [ 31–33 ] properties and act as inhibitors for COX‐2, [ 22 ] potent antiangiogenic agents in atherosclerosis, [ 31 ] and potent immunomodulatory agents. [ 34 ] They play a role in the treatment of Alzheimer's disease [ 35,36 ] and inhibit the corrosion of mild steel in acidic media. [ 37 ] They are also used in the detection of some ions [ 38,39 ] and as colorimetric chemosensors for expeditious detection of CN − in aqueous media, [ 40 ] as well acting as a catalyst in several reactions.…”

Tridentate N-Acylhydrazones as Moderate Ligands for the Potential Management of Cognitive Decline Associated With Metal-Enhanced Neuroaggregopathies

“…Among these, pyridine-2-carboxaldehyde ( N -adamantan-1-yl)benzoyl-4-amidohydrazone, namely 10, was identified as a lead compound. One year later, the group of Alptuzun described a set of piperidinehydrazide-hydrazones as potential anti-Alzheimer's agents ( 20 ). Although the N -acylhydrazones evaluated by these authors are not tridentate ligands, so their affinity for biometals is probably low and was not verified, their acetylcholinesterase and butyrylcholinesterase inhibitory activities, as well as the ability to prevent Aβ 1−42 self-aggregation, illustrate the versatility of the class and certainly make them worthy of reference.…”

Synthesis, Characterization, PXRD Studies, Theoretical Calculation, and Antitumor Potency Studies of a Novel N,O‐Multidentate Chelating Ligand and Its Zr(IV), V(IV), Ru(III), and Cd(II) Complexes

“…Numerous studies have con rmed that the hydrazone and carbaldehyde derivatives and their complexes have a wide series of biological properties [8][9][10][11], such as anticancer [12][13][14][15], antibacterial [16][17][18], antimicrobial [19][20][21], antifungal [22,23], antimalarial [24], antiviral [25], antimycobacterial [12,26], antileishmanial [25,27], antiplatelet [28], antianalgesic, antitubercular, anticonvulsant [29], antiuropathogenic [30], antiproliferative [31], antiarthritic [32], and antioxidant [33][34][35] properties and are potent immunomodulatory agents [36] and antiangiogenic agents in atherosclerosis [33]. Moreover, they play an important role in treating Alzheimer's disease [37,38]. Recently, a new ligand of ((Z)-2-(phenylamino)-N'-(thiophen-2-ylmethylene) acetohydrazide) [39] was used to synthesis Pd(II), Cd(II), Cu(II), and Cu(I) complexes, where the ligand behaves as a neutral bidentate or tetradentate,thePd(II) complexissquare planar,and Cu(II) and Cu(I) complexes are square pyramidal in geometry.…”