Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives

Rothe, Marlene L.; Li, Jie; Garibay, Ernesto; Moore, Bradley S.; McKinnie, Shaun M. K.

doi:10.1039/c8ob03109f

Cited by 5 publications

(2 citation statements)

References 46 publications

(60 reference statements)

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“…YD also reversed NNMT-mediated resistance of non-small cell lung cancer cells to 5-FU [124]. The anti-bacterial compound thiotetramycin and its derivatives demonstrated mild inhibitory effects against NNMT [212]. JBSNF-000088 (a substrate inhibitor) [201,202], 6-methylaminonicotinamide [213] and methylated quinolinium analogues such as 5-amino-1-methylquinoline [34,214], are nicotinamide analogues which all have IC 50 values in the single µM range.…”

Section: Nicotinamide Analoguesmentioning

confidence: 99%

Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution

Parsons

Facey

2021

Biomolecules

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Nicotinamide N-methyltransferase (NNMT) has progressed from being considered merely a Phase II metabolic enzyme to one with a central role in cell function and energy metabolism. Over the last three decades, a significant body of evidence has accumulated which clearly demonstrates a central role for NNMT in cancer survival, metastasis, and drug resistance. In this review, we discuss the evidence supporting a role for NNMT in the progression of the cancer phenotype and how it achieves this by driving the activity of pro-oncogenic NAD+-consuming enzymes. We also describe how increased NNMT activity supports the Warburg effect and how it promotes oncogenic changes in gene expression. We discuss the regulation of NNMT activity in cancer cells by both post-translational modification of the enzyme and transcription factor binding to the NNMT gene, and describe for the first time three long non-coding RNAs which may play a role in the regulation of NNMT transcription. We complete the review by discussing the development of novel anti-cancer therapeutics which target NNMT and provide insight into how NNMT-based therapies may be best employed clinically.

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Section: Nicotinamide Analoguesmentioning

confidence: 99%

Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution

Parsons

Facey

2021

Biomolecules

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“…13). 104,105 The tlm gene cluster was then heterologously expressed in Streptomyces coelicolor using a TAR cloning strategy, which resulted in the identification of thiolactomycin and three new analogues. Later, mutagenesis and comparative metabolic analyses revealed the involvement of tlmF-tlmI genes in the γ-thiolactone skeleton construction of this class of antibiotics.…”

Section: Thiolactomycin and Thiotetromycinsmentioning

confidence: 99%

Recent highlights of biosynthetic studies on marine natural products

et al. 2021

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Converging thiolactone and quinoline scaffolds: New potential antitubercular conjugates

Azeeza,

Malik,

Alsimaree

et al. 2024

Journal of Molecular Structure

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Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives

Abstract: Interrogating the bioactivities and enzymatic modification potential of a focused library of novel synthetic thiotetronate compounds.

Cited by 5 publications

References 46 publications

Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution

Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution

Recent highlights of biosynthetic studies on marine natural products

Converging thiolactone and quinoline scaffolds: New potential antitubercular conjugates

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