Synthesis, antitumor and antimicrobial activities of 4-(4-chlorophenyl)-3-cyano-2-(β-O-glycosyloxy)-6-(thien-2-yl)-nicotinonitrile

O‐Glycosylation/Alkylation and Antimicrobial Activity of 4,6‐Diaryl‐2‐Oxonicotinonitrile Derivatives

“…2‐Oxo‐4,6‐diaryl‐1,2‐dihydropyridine‐3‐carbonitrile 1a , 1b were obtained according to the literature by one‐pot multi‐component reaction of 3‐acetyl phenantherene, ethyl cyanoacetate and aromatic aldehydes in the presence of NH 4 OAc/EtOH (Scheme ). The structure of 1a , 1b was elucidated by spectral analysis (IR, 1 H/ 13 C NMR and elemental analysis).…”

“…As a part of our ongoing program for the synthesis of 2‐oxopyridinecarbonitrile derivatives as potential biologically active compounds [18‐20], herein, we reported on the glycosylation and alkylation of 2‐oxo‐4‐aryl‐6‐phenanthrenyl‐1,2‐dihydropyridine‐3‐carbonitrile 1a , 1b derivatives and their evaluation as potential antimicrobial agents.…”

Conventional and Microwave‐Activated the Synthesis of a Novel Series of Imidazoles, Pyrimidines, and Thiazoles Candidates

“…Recently, several protocols have already been described the synthesis of thiazoles and benzothiazoles derivatives [6][7][8]. The new trend for the synthetic of compounds uses microwave irradiation (MWI) as a powerful technique for rapid and efficient synthesis [15][16][17]. Several pyrimidine derivatives exhibit diverse pharmacological activities [9,10], as antimicrobial [11], analgesic [12], anti-inflammatory [13], and antitumor activity [14].…”

One‐Pot Synthesis of 3‐Cyano‐2‐pyridones

“…Other examples in preclinical development include A‐769662 (AMPK activator for metabolic disorders) and JNJ‐40068782 (metabotropic glutamate receptor mGluR2 modulator for psychiatric disorders) . In addition to the continuous interest of being explored as cardiotonic agents , 3‐cyano‐2‐pyridones were also explored as antitumor , anticoagulant , anti‐inflammatory, and analgesic agents .…”

“…The majority of the recent syntheses of 3‐cyano‐2‐pyridones utilized a one‐pot four‐component condensation (ethyl cyanoacetate, aromatic aldehydes, aromatic ketones, and excess of ammonium acetate) in refluxing ethanol or 2‐butanol [41,42]. As a significant improvement from the multiple step reactions, this method offers easy operation and quick assembly from readily available aldehydes and ketones.…”