<i>O</i>‐Glycosylation/Alkylation and Antimicrobial Activity of 4,6‐Diaryl‐2‐Oxonicotinonitrile Derivatives

Haggam, Reda A.; El‐Sayed, Hassan A.; Said, Sameh M.; Ahmed, Mohammed H.; Moustafa, A. H.; Abd-El-Noor, R. E.

doi:10.1002/jhet.2593

Cited by 18 publications

(11 citation statements)

References 18 publications

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“…Nevertheless, (K3 and K6) were 100% since 5hr. The negligible inhibitory concentration for newly synthesized compounds presented high important activity against SA [6][7].…”

Section: Resultsmentioning

confidence: 93%

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In-Vitro Biological Experiment for New Pharmacology Compounds at High-Altitude-Area, Taif, KSA

2019

International Journal of Research Studies in Biosciences

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This paper was discharged for "In-vitro biological experiment for new pharmacology compounds at high-altitude-area (HAA), Taif, KSA". The mean of antimicrobial effects on Staphylococcous aureus (SA), as antibacterial effect were at (1, 3, 5 and 7hr). The mean antimicrobial were in descendant order by antibacterial as followed (K1, K2, k3, K4, K5 and K6) were 100% at 7hr. Nevertheless, (K3 and K6) were 100% since 5hr. The newly synthesized compounds inhibitory concentration presented high important activity against SA. The mean of antimicrobial effects on Escherichia coli (EC), as antibacterial more effective (K1, K2, K3 and K5) were 100% at 7hr, then (K4 and K5) were (95 and 90%). The mean antibacterial during the exposure hrs and the averages were in descendent command by antibacterial fraction. The inhibitory concentration presented by using pharmacology compounds high important activity against EC. The mean of antimicrobial effects on Candida albicans (CA), the effect as antifungal were included (1, 3, 5 and 7hr). The means were in descendant order by the fraction of antifungal, the more effective were (K2, K3 and K6) were 100% at 7hr, and then (K1, K4 and K5) were (90, 95 and 85%). The effective was clear with pharmacology compounds. This present applied work concluded pharmacology compounds had effective more powerful than antimicrobial agents did. As well, it could be institution of antimicrobial agents for "Health-program" (HP) at HAA. Using new pharmacology compounds instead of chemical antimicrobial substances to protect human body from side effects and could improve HP at HAA.

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“…Nevertheless, (K3 and K6) were 100% since 5hr. The negligible inhibitory concentration for newly synthesized compounds presented high important activity against SA [6][7].…”

Section: Resultsmentioning

confidence: 93%

“…The progress of well-organized midazole romped a main in current biological mixture [5]. The negligible inhibitory attention for manufactured mixes exhibited in height significant antimicrobials [6]. Sequences of derivatives were killed SA, EC and CA [7].…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Biological Experiment for New Pharmacology Compounds at High-Altitude-Area, Taif, KSA

2019

International Journal of Research Studies in Biosciences

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“…3. The minimal inhibitory concentration for some of the newly synthesized compounds showed high significant activity against fungi activities 26 , their antimicrobial activity fungi (C. albicans) showed significant antimicrobial activity against tested microorganisms 28 . 2.…”

Section: Antimicrobial: A) Antibacterialmentioning

confidence: 96%

Untitled

2018

IJPSR

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In the field of the preparation of chemotherapeutic agents with new mechanism distinct from currently approved drugs is important. However, the clinically effective approved small inhibitor molecule is still lacking. Previous reports indicated that 4-aryl-2-hydrazinothiazole derivatives provided a useful start point to develop HAT inhibitors (histone acetyltransferase). Consequently, preparation and biological evaluation of a focused library of 4-aryl-2-hydrazinothiazole based derivatives as useful as anti-cancer agents. Synthesis of 4-aryl-2-hydrazinothiazoles (1a-d), (2a-d), (3a-c), (4a-b), (5a-b), (6a-b) studied by either conventional method and free solvent microwave one-pot method, and the synthesized compounds were proved by spectroscopic methods (IR, 1 HNMR, 13 CNMR, GC-Ms, and elemental analysis). The activity against different cancer cell lines and the antimicrobial activities different organisms also studied, and all of the synthesized compounds were of high activity as an antibacterial for gram positive and gram negative; however, it showed also an antifungal activity were the most active compounds were 4a, 4b, 5b, 6a. It was found that all of the prepared thiazoles derivatives were active toward many cell lines (breast, liver, and prostate) where the more active compounds were 4a, 4b, and 6a. Molecular docking studies guided and proved the biological activities of these novel 4-aryl-2-hydrazinothiazoles.

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“…A mixture of 1a,b (10 mmol), epichlorohydrin (10 mmol) was added to dry DMF (10 ml) in the presence of anhydrous K 2 CO 3 (11 mmol), the reaction mixture was heated under reflux for 12 hours [31], cooled and poured onto ice water, the precipitate was collected, dry and recrystallization from methanol.…”

Section: Alkylation With Epichlorohydrinmentioning

confidence: 99%

Synthesis of some bioactive compounds and its application as antimicrobial agents for Plastic industry

Zaiton¹,

Assem

Arafa

et al. 2018

Egypt. J. Chem.

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N EW biocidal compounds were synthesized by reacting 4-hydroxy acetophenone with ethyl cyanoacetate and 2-chlorobenzaldehydes and ammonium acetate in absolute ethanol to give 4-(2-chlorophenyl)-2-hydroxy-6-(4-hydroxyphenyl) nicotinonitrile which by epoxidation gives 4-(2-chlorophenyl)-6-(4-(oxiran-2-ylmethoxy) phenyl)-2-oxo-1,2-dihydropyridine-3carbonitrile. Another compound was synthesized by reacting 4-hydroxy acetophenone with ethyl cyanoacetate and 4-nitrobenzaldehydes and ammonium acetate in absolute ethanol to give 2-hydroxy-6-(4-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitrile witch by epoxidation gives 4-(4-nitrophenyl)-6-(4-(oxiran-2-ylmethoxy) phenyl)-2-oxo-1,2-dihydropyridine-3carbonitrile. The synthesized four compounds and standard biocide (Zn omadine) were added separately to LDPE and HDPE and polystyrene in the same ratio (0.1 phr) followed by studying the melt flow rate and mechanical properties and electrical properties of LDPE and HDPE and polystyrene. In addition the biological activity of the prepared blends with LDPE or HDPE or PS were studied against two local isolates E. coli sero type O145 as gram-negative bacteria and S. epidermidis as gram-positive bacteria The antimicrobial test was performed quantitatively using the standard test method.

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O‐Glycosylation/Alkylation and Antimicrobial Activity of 4,6‐Diaryl‐2‐Oxonicotinonitrile Derivatives

Cited by 18 publications

References 18 publications

In-Vitro Biological Experiment for New Pharmacology Compounds at High-Altitude-Area, Taif, KSA

In-Vitro Biological Experiment for New Pharmacology Compounds at High-Altitude-Area, Taif, KSA

Untitled

Synthesis of some bioactive compounds and its application as antimicrobial agents for Plastic industry

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