Synthesis, antimicrobial and antiviral activities of isotrimethoprim and some related derivatives

3,4-Dihydro-2-Alkoxy-6-Benzyl-4-Oxopyrimidines (DABOs): A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1

“…The anti-HIV activity in chronically infected H9/111B cells was examined by measuring the infectious virus titre in C8166 cells as previously described (Botta et al, 1992).…”

Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

“…Since the rst series of DABOs were disclosed as a novel class of NNRTIs in 1992, 6 many structural modications have been made and led to the discovery of numerous promising DABO families such as S-DABOs, N-DABOs, DATONs, DABOCs and a-methyl-DABOs (Fig. 1).…”

Computational modeling studies on anti-HIV-1 non-nucleoside reverse transcriptase inhibition by dihydroalkoxybenzyloxopyrimidines analogues: an electrotopological atomistic approach

“…Dihydroalkoxybenzyloxopyrimidines (DABO) derivatives have been successfully used as HIV-1 reverse transcriptase inhibitors [24] and are useful precursors for deriving novel potent compounds. The first step of rational drug design often consists of performing QSAR modeling, based on congeneric structures of ligands; this procedure has been carried out by several researchers for a class of DABO derivatives [25][26][27][28].…”