3,4-Dihydro-2-Alkoxy-6-Benzyl-4-Oxopyrimidines (DABOs): A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1

Crystal structure of 6-(phenylsulfanyl)-5-propylpyrimidine-2,4(1H,3H)- dione, C13H14N2O2S

“…The chemotherapeutic efficacy of uracil and pyrimidine derivatives is related to their ability to inhibit vital enzymes responsible for DNA biosynthesis such as dihydrofolate reductase (DHFR), thymidylate synthetase (TSase), thymidine phosphorylase (TPase) and reverse transcriptase (RTase). Pyrimidine-2,4-diones and their related derivatives have long been known for their diverse chemotherapeutic activities including antiviral activity against HIV [1][2][3][4][5] and HSV viruses [6]. In addition, potent anticancer [7][8][9][10] and antimicrobial activities [11,12] was observed for several pyrimidine-2,4-diones.…”

Crystal structure of 5-ethyl-6-[(3-methylphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione, C13H14N2O2S

“…The chemotherapeutic e cacy of pyrimidine-related derivatives is related to their ability to inhibit vital enzymes responsible for DNA biosynthesis including dihydrofolate reductase (DHFR), thymidylate synthetase (TSase), thymidine phosphorylase (TPase) and reverse transcriptase (RTase). 1-[2-(Hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) and its derivatives have long been known for their potent activity against human immunode ciency viruses (HIV) [1][2][3][4][5][6][7]. In addition, numerous pyrimidine-related derivatives displayed marked activities against herpes simplex viruses (HSV) [8], and hepatitis B viruses (HBV) [9].…”

Crystal structure of 6-oxo-4-propyl-2-(propylthio)-1,6-dihydropyrimidine-5-carbonitrile, C11H15N3OS

“…Non-nucleoside pyrimidine-based derivatives have long been known as potent anticancer drugs [1][2][3][4]. Large array of pyrimidine-based analogues have emerged as useful therapies against human immunode ciency viruses (HIV) [5][6][7][8], hepatitis B viruses (HBV) [9], herpes simplex viruses (HSV) [10,11], in uenza viruses [12] and varicella-zoster virus (VZV) [13]. Moreover, several pyrimidine derivatives were reported to display antibacterial [14][15][16][17] and antifungal [18] activities.…”