2015
DOI: 10.1515/ncrs-2015-0012
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Abstract: Source of materialA mixture of 6-chloro-5-propyluracil (943 mg, 5 mmol), thiophenol (551 mg, 5 mmol) and potassium hydroxide (281 mg, 5 mmol), in ethanol (10 mL), was heated under reflux for three hours. DiscussionPyrimidine-2,4(1H,3H)-dione (uracil) is an important pharmacophore found in many chemotherapeutic agents. The chemotherapeutic efficacy of uracil and pyrimidine derivatives is related to their ability to inhibit vital enzymes responsible for DNA biosynthesis such as dihydrofolate reductase (DHFR), t… Show more

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