Synthesis, antibacterial screening and DFT studies of series of α-amino-phosphonates derivatives from aminophenols

Hellal, Abdelkader; Chafaa, Salah; Chafai, Nadjib; Touafri, Lasnouni

doi:10.1016/j.molstruc.2016.12.079

Cited by 48 publications

(9 citation statements)

References 26 publications

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“…Additionally, the quantum chemical calculations using Density Functional Theory (DFT) method are largely employed to determine the active sites of drugs and to correlate their activity with various quantum chemical parameters [14] , [15] , [16] . In this context, several biological activities of the bioactive molecules can be extensively studied using the DFT calculations [17] , [18] , [19] .…”

Section: Introductionmentioning

confidence: 99%

New α-Hydrazinophosphonic acid: Synthesis, characterization, DFT study and in silico prediction of its potential inhibition of SARS-CoV-2 main protease

Benbouguerra

Chafai

Chafaa

et al. 2021

Journal of Molecular Structure

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Section: Introductionmentioning

confidence: 99%

New α-Hydrazinophosphonic acid: Synthesis, characterization, DFT study and in silico prediction of its potential inhibition of SARS-CoV-2 main protease

Benbouguerra

Chafai

Chafaa

et al. 2021

Journal of Molecular Structure

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“…For that, the anticorrosion activity of synthetic product has been evaluated using the difference absorbance method and the surface of mild steel analysis using SEM/EDX technical. The theoretical study represents a global analysis that gives information on several parameters, among them; we find the energy value of the free enthalpy of the reaction that demonstrates us, not only the spontaneity of the reaction but also its exact energy value 35,36 .…”

Section: Introductionmentioning

confidence: 94%

New strategy of synthesis, characterization, theoretical study and inhibition effect on mild steel corrosion in acidic solution

Arrousse¹,

Mabrouk²,

Hammouti³

et al. 2020

Mediterr.J.Chem.,

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We report two new different synthesis strategies of an eco-friendly organic dye 3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate. These methods were based on the reaction of fluorescein with acetic anhydride under different experimental conditions. The synthesized heterocyclic system obtained with excellent yield was characterized by FT-IR, 1H N.M.R., 13C N.M.R., and mass spectrometry. This reaction has also been studied theoretically using Gaussian 09 based on the DFT method at B3LYP/6-31G (d, p). The results obtained are in good correlation with those obtained experimentally. The inhibition behavior of the synthetic product has been studied using absorbance difference measurement, the percentage of inhibition efficiency attains 90% at 10-4M of NAR3 inhibitor. The surface analysis of mild steel was investigated using scanning electron microscopy (S.E.M.) and Energy Dispersive X-ray (E.D.X.) methods and show the adsorption behavior of inhibitor on the surface of mild steel.

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“…The condensation of aminophenols, benzaldehyde derivatives, and dimethyl phosphite was performed in an aqueous medium containing oxalic acid as the catalyst at 90 °C. No yields were achieved ( Scheme 23 ) [ 46 ].…”

Section: Kabachnik–fields Reactions With Dialkyl Phosphites Alkyl H -Phosphinates and Secondary Phosphine Oxidesmentioning

confidence: 99%

Synthesis of α-Aminophosphonates and Related Derivatives; The Last Decade of the Kabachnik–Fields Reaction

Varga

Keglevich

2021

Molecules

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The Kabachnik–Fields reaction, comprising the condensation of an amine, oxo compound and a P-reagent (generally a >P(O)H species or trialkyl phosphite), still attracts interest due to the challenging synthetic procedures and the potential biological activity of the resulting α-aminophosphonic derivatives. Following the success of the first part (Molecules 2012, 17, 12821), here we summarize the synthetic developments in this field accumulated in the last decade. The procedures compiled include catalytic accomplishments as well as catalyst-free and/or solvent-free “greener” protocols. The products embrace α-aminophosphonates, α-aminophosphinates, and α-aminophosphine oxides along with different bis derivatives from the double phospha-Mannich approach. The newer developments of the aza-Pudovik reactions are also included.

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Synthesis, antibacterial screening and DFT studies of series of α-amino-phosphonates derivatives from aminophenols

Cited by 48 publications

References 26 publications

New α-Hydrazinophosphonic acid: Synthesis, characterization, DFT study and in silico prediction of its potential inhibition of SARS-CoV-2 main protease

New α-Hydrazinophosphonic acid: Synthesis, characterization, DFT study and in silico prediction of its potential inhibition of SARS-CoV-2 main protease

New strategy of synthesis, characterization, theoretical study and inhibition effect on mild steel corrosion in acidic solution

Synthesis of α-Aminophosphonates and Related Derivatives; The Last Decade of the Kabachnik–Fields Reaction

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