Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

Abstract

Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy] ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

Base‐Mediated Syntheses of Di‐ and Trisubstituted Imidazoles from Amidine Hydrochlorides and Bromoacetylenes

“…Due to their occurrence in natural products and other bioactive molecules, imidazole structures have long been a focus of synthetic chemistry 1. 2 Compounds with substituted imidazole cores include angiotensin receptor blockers,3 agents with antitumor4 and anticancer activities,5 antibacterial and potential anti‐HIV agents,6 and drugs with antiparasitic activity 7. Furthermore, 2,4(5)‐diarylimidazoles have been reported to be inhibitors of hNaV1.2 sodium channels 8…”

Azoles as Potent Antimicrobial Agents

“…Giraldi et al [15] in year 1967, synthesized a series of 1-aminoalkyl and 1aminoalkyl-2-methyl-5(4)-nitro-4(5)-styrylimidazoles (30)(31)(32)(33)(34)(35)(36)(37) and these compounds were tested to check the potency of synthesized compounds against various non-pathogenic bacteria and fungi.…”

“…Ganguly et al [33] in the year 2011, reported some novel imidazole analogs of the type (261-274) and evaluated their antibacterial and anti-HIV activity.…”

Stereoselective synthesis of 2′-modified nucleosides by using ortho-alkynyl benzoate as a gold(i)-catalyzed removable neighboring participation group

“…1 Among these chemical entities, C-2 0 substituted nucleosides have showed special importance. [2][3][4][5] For instance, clofarabine, gemcitabine, nelarabine, clofrabine and most recently FDA approved sofosbuvir for chronic HCV treatment all contain the C-2 0 substituted nucleoside core structure (Fig. 1).…”