Azoles as Potent Antimicrobial Agents

Singh, Rohit; Ganguly, Swastika

doi:10.5772/intechopen.88547

Cited by 4 publications

(5 citation statements)

References 38 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antibacterial capability of these membranes may not be solely attributed to the presence of silver. Imidazole and its derivatives have also shown antiviral, antibacterial, and antifungal effects. , In a recent study conducted to evaluate the antibacterial activity of three imidazole-based Ag-containing MOFs, Ag-2 methylimidazole demonstrated the highest antibacterial activity, owing to its high silver content and unique nanocrystal structure with sharp edges that can provide better interaction with bacteria . Please see further information in Figure S4 of the Supporting Information.…”

Section: Results and Discussionmentioning

confidence: 99%

In Situ Ag-MOF Growth on Pre-Grafted Zwitterions Imparts Outstanding Antifouling Properties to Forward Osmosis Membranes

Pejman

Firouzjaei

Aktij

et al. 2020

ACS Appl. Mater. Interfaces

103

View full text Add to dashboard Cite

In this study, a polyamide forward osmosis membrane was functionalized with zwitterions followed by the in situ growth of metal–organic frameworks with silver as a metal core (Ag-MOFs) to improve its antibacterial and antifouling activity. First, 3-bromopropionic acid was grafted onto the membrane surface after its activation with N , N -diethylethylenediamine. Then, the in situ growth of Ag-MOFs was achieved by a simple membrane immersion sequentially in a silver nitrate solution and in a ligand solution (2-methylimidazole), exploiting the underlying zwitterions as binding sites for the metal. The successful membrane functionalization and the enhanced surface wettability were verified through an array of characterization techniques. When evaluated in forward osmosis tests, the modified membranes exhibited high performance and improved permeability compared to pristine membranes. Static antibacterial experiments, evaluated by confocal microscopy and colony-forming unit plate count, resulted in a 77% increase in the bacterial inhibition rate due to the activity of the Ag-MOFs. Microscopy micrographs of the Escherichia coli bacteria suggested the deterioration of the biological cells. The antifouling properties of the functionalized membranes translated into a significantly lower flux decline in forward osmosis filtrations. These modified surfaces displayed negligible depletion of silver ions over 30 days, confirming the stable immobilization of Ag-MOFs on their surface.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

In Situ Ag-MOF Growth on Pre-Grafted Zwitterions Imparts Outstanding Antifouling Properties to Forward Osmosis Membranes

Pejman

Firouzjaei

Aktij

et al. 2020

ACS Appl. Mater. Interfaces

103

View full text Add to dashboard Cite

show abstract

“…ZnO-NPs are widely use to synthesis various heterocyclic compounds such as diazepine, benzofuran, coumarin, pyrido, pyrimidine, pyrones, and various azoles. Utilization of these heterocyclic derivatives increasing day by day in pharmaceutical as well as agrochemical field, and obtained the significant result in anti-fungal, [101,102] anti-malarial, [103][104][105] anti-bacterial, [106,107] antimicrobial, [108,109] anti-oxidants, [110,111] anti-cancer [112][113][114][115] etc. Due to their flammable characteristics, several tetrazoles and triazoles, such as tetrazole with 5-aminotetrazole, are used as parts of gas Figure 1.…”

Section: Synthesis Of Triazoles and Tetrazoles Derivativesmentioning

confidence: 99%

Zinc Oxide Nanoparticles as Efficient Heterogeneous Catalyst for Synthesis of Bio‐active Heterocyclic Compounds

Kumar,

Tomar,

Kumar

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

Among the most effective recoverable catalytic systems, metal‐oxide nanoparticles (NPs) are well known for their extensive uses in a broad range of industries, pharmaceuticals, and nano‐biotechnology. In addition, heterogeneous catalysis uses clearly defined materials which are present an extensive range of new possibilities for the research and production of innovative catalysts that help to solve the world's energy and environmental problems. ZnO‐NPs have been used as effective nanocatalysts according to the literature for various kinds of organic reactions. The extensive advantages of ZnO‐NPs over bulk materials suggest that this is a promising field for further research. This review article provides an in‐depth overview of the several ZnO‐NPs that have been reported to catalyse organic transformations including the production of bio‐active compounds like benzofuran, coumarin, imidazole, indole, pyrazole, pyridine pyrimidine, thiazole, diazepine, azoles derivatives. Recent synthetic routes for modifying and functionalizing ZnO‐NPs to increase their catalytic efficacy were also addressed, and illustrated with schematics. The development of novel, highly effective, and reusable modified ZnO‐NPs as catalysts, which would clear the way for the establishment of greener and sustainable technologies, provides the key to the future of catalysis. Researchers attempting to synthesise new functionalized ZnO‐NPs for sustainable development will find this review informative.

show abstract

“…Giust et al developed a process of substituted 1H-tetrazoles from aromatic or aliphatic isonitriles, and trimethylsilyl azide can be catalyzed by the hexameric capsule of resorcin [4]arene as a supramolecular self-assembled catalyst. [114] The encapsulation of the reagents accelerates the reaction in the cavity of the supramolecular catalyst.…”

Section: Homogenous Catalystsmentioning

confidence: 99%

“…Tetrazoles and their derivatives can be utilized as a bio-isosteric replacement to carboxylic acids resulting in their all-important and major part of the applications in medicinal chemistry. Many of the tetrazole derivatives are used as anticancer, [2,3] antibacterial, [4,5] anti-inflammatory, [6,7] analgesic, [7] anti-allergic, [8] antifungal, [3,9] antiulcer [10] etc. They have also found herbicide, fungicide, and plant growth regulator applications in agriculture.…”

Section: Introductionmentioning

confidence: 99%

Advances in Tetrazole Synthesis – An Overview

2022

View full text Add to dashboard Cite

Most of the active pharmaceutical ingredients (API) contain the tetrazole ring, thus making them of vast significance in new drug design descriptors. With this importance in view, enormous studies are being carried out on the synthesis of tetrazole derivatives. The methods of its synthesis are [3+2] cycloaddition, multicomponent reactions, microwave‐assisted synthesis using heterogeneous and homogeneous catalysts. Hence, it is necessary to highlight the green catalysis that would be more environmentally benign and economically viable. In this review, we discuss the tetrazole synthesis processes carried out in the presence of heterogeneous and homogeneous catalysts. These catalytic materials gave higher product yield in a shorter reaction time and were reusable.

show abstract

Azoles as Potent Antimicrobial Agents

Cited by 4 publications

References 38 publications

In Situ Ag-MOF Growth on Pre-Grafted Zwitterions Imparts Outstanding Antifouling Properties to Forward Osmosis Membranes

In Situ Ag-MOF Growth on Pre-Grafted Zwitterions Imparts Outstanding Antifouling Properties to Forward Osmosis Membranes

Zinc Oxide Nanoparticles as Efficient Heterogeneous Catalyst for Synthesis of Bio‐active Heterocyclic Compounds

Advances in Tetrazole Synthesis – An Overview

Contact Info

Product

Resources

About