Synthesis, antibacterial and antitubercular activities of benzimidazole bearing substituted 2-pyridone motifs

Desai, N. C.; Shihory, Niraj; Kotadiya, G. M.; Desai, Priyanka

doi:10.1016/j.ejmech.2014.06.004

Cited by 59 publications

(35 citation statements)

References 35 publications

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“…Moreover, 2-pyridones are a class of newly exposed potent antibacterial agents that are of specific concern due to their in vitro and in vivo antibacterial potencies against the bacterial type II DNA topoisomerases, which consist of two highly homologous enzymes-DNA gyrase and topoisomerase IV [22,23]. In accordance with our previous work [24,25,26] and medicinal importance of coumarin and 2-pyridone motifs we report herein the synthesis of a new class of 6-((arylidene)amino)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o as potential antimicrobial agents.…”

Section: Introductionsupporting

confidence: 61%

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

Desai

Karkar

2016

ILCPA

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Abstract:The synthesis of a novel series of 6-((arylidene)amino)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o were synthesized and structures of compounds have been elucidated by IR, 1 H NMR, 13 C NMR and mass spectral data. Antimicrobial activity was measured against certain strains of bacteria and fungi by serial broth dilution. Evaluation of antimicrobial activity shown that the compounds (4g, 4j, 4k and 4o) were found to be most active against selected bacterial strains and compounds (4d, 4m and 4n) were found to be most active against selected fungal strains.

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Section: Introductionsupporting

confidence: 61%

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

Desai

Karkar

2016

ILCPA

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“…In continuation of our previous work [28][29][30][31] and because of the medicinal importance of thiazole and 1,3,4-oxadiazole, we report herein synthesis of a new class of N-(4-methyl-5-(4-((substituted phenylamino)methyl)-5-thioxo-4,5-dihydro- 1,3,4-oxadiazol-2-yl)thiazol-2-yl)benzamides (5a-k). We also tried to develop potential antimicrobials.…”

Section: Introductionmentioning

confidence: 90%

Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

et al. 2015

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In an effort to find a new pharmacologically dynamic molecule, we report here the synthesis and in vitro antimicrobial activity of various N-(4-methyl-5-(4-((substituted phenylamino) methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl) benzamides. The structures of newly synthesized compounds were assigned on the bases of IR, 1 H NMR, 13 C NMR, and mass spectral data. Synthesized compounds were screened for their antibacterial and antifungal activities on gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), gramnegative bacteria (Escherichia coli and Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial broth dilution method. Compounds 5e and 5k were associated with considerable potential antibacterial and compounds 5a and 5b antifungal activities.

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“…Being structural surrogates of nucleotides, benzimidazole derivatives exhibited the potential to interact with proteins, enzymes and receptors. Substituted benzimidazoles were found to possess various biological activities such as antibacterial [3] , antiinflammatory [4] , antifungal [5] , antitubercular [6] , anticancer [7] , anticonvulsant and antidiabetic [8] . A number of 2-thio-1H-benzimidazole derivatives have been demonstrated to exhibit potent antiparasitic [9,10] activities.…”

Section: Research Papermentioning

confidence: 99%

Synthesis, Spectral Characterization and Antimicrobial Studies of New Hybrid Heterocyclic Compounds Bearing 1H-benzimidazol-2-yl Thiomethyl Motif

Deshp¹,

Chavan²,

Nagarale³

et al. 2017

pharmaceutical-sciences

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Deshpande, et al.: Compounds with 1H-benzimidazol-2-yl Thiomethyl MotifTo understand the biological importance of heterocyclic cores, novel 1H-benzimidazol-2-yl thiomethyl incorporated hybrid compounds, 2-(benzimidazol-2-ylthiomethyl)-5-aryl-1,3,4-oxadizoles and 1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)pyridazine/phthalazinediones were designed using molecular hybridization technique, synthesized and characterized. The compounds were screened for in vitro antimicrobial activity using the serial dilution technique and were found to exhibit weak antitubercular activity, excellent to moderate antibacterial and better antifungal activities against some tested organisms in comparison to the standard drugs. Thus, some of the title compounds demonstrated antimicrobial activity.

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Synthesis, antibacterial and antitubercular activities of benzimidazole bearing substituted 2-pyridone motifs

Cited by 59 publications

References 35 publications

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

Synthesis, Spectral Characterization and Antimicrobial Studies of New Hybrid Heterocyclic Compounds Bearing 1H-benzimidazol-2-yl Thiomethyl Motif

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