Deshpande, et al.: Compounds with 1H-benzimidazol-2-yl Thiomethyl MotifTo understand the biological importance of heterocyclic cores, novel 1H-benzimidazol-2-yl thiomethyl incorporated hybrid compounds, 2-(benzimidazol-2-ylthiomethyl)-5-aryl-1,3,4-oxadizoles and 1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)pyridazine/phthalazinediones were designed using molecular hybridization technique, synthesized and characterized. The compounds were screened for in vitro antimicrobial activity using the serial dilution technique and were found to exhibit weak antitubercular activity, excellent to moderate antibacterial and better antifungal activities against some tested organisms in comparison to the standard drugs. Thus, some of the title compounds demonstrated antimicrobial activity.
In the present study was undertaken to evaluate the mucilage obtained from the calyx of flower of Hibiscus rosasinensis Linn as a suspending agent. A suspension of CaCO3 was prepared using 2 % w/v of hibiscus mucilage as suspending agent and it is evaluated for its stability using the parameters like, sedimentation volume, viscosity, redispersibility and pH. The suspending effect of hibiscus mucilage was compared with CaCO3 suspensions prepared using 2 % w/v of suspending agents such as acacia and tragacanth. The results obtained indicated that the hibiscus mucilage could be used as a suspending agent. It has low rate of sedimentation, high viscosity, slightly basic pH and is easily redispersible. These effects were comparable with that of the standard suspending agents like acacia and tragacanth. The mucilage isolated from the calyx of flower of Hibiscus rosasinensis can be used as a pharmaceutical adjuvant.
Cancer cause sickness and consequently can be viably overwhelmed by a multi-constituently remedial strategy. Herbal extracts shows the example of such stratagem. However, less research have been carried out till date that portray the effect of different extraction techniques on the phyto compounds profile of plant extracts and its effect on anticancer activity. Momordica charantia is a member of the Cucurbitaceae. It is a popular vegetable harvest in Indian customary medicine since olden times. It has potential lipid lowering and antioxidant activity and antidiabetic. In the present study, we have evaluated the anticancer prospective of methanolic and acetone extracts of Momordica charantia (MCME) and (MCAE). Reported results show that (MCME) is rich in bioactive compounds shown anticancer activity with Cell lines of (IC50) with MCF 715.6 ± 1.3 and HeLa 28.2 ± 1. This study based on the presence of cytotoxic from the Momordica charantia, which have been further used in herbal formulations study as an anticancer activity. Our conclusion support additional indepth study of this pharmacologic activity as a malignant tumour agent.
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