Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases

Sondhi, Sham M.; Singh, Nishan; Kumar, Ashok; Lozach, Olivier; Meijer, Laurent

doi:10.1016/j.bmc.2006.01.054

Cited by 295 publications

(133 citation statements)

References 19 publications

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“…Some Schiff bases show biological activities such as anti-inflammatory, antimicrobial, anticonvulsant, anticancer, analgesic etc. [2][3][4]. And also, their metal complexes often exhibit antibacterial, antiviral, fungicidal or antitubarculoral activity [5,6].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C₁₇H₁₂N₂O₃

Bülbül

Köysal

Macit

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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CCDC no.: 1484947The asymmetric unit of the title crystal structure is shown in the figure. Tables 1 and 2 contain details on crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Source of material(E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol was prepared by refluxing a mixture of a solution containing 5-hydroxy-2-nitro-benzaldehyde (8.4 mg, 0.05 mmol) in

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Section: Discussionmentioning

confidence: 99%

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C₁₇H₁₂N₂O₃

Bülbül

Köysal

Macit

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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“…anti-oxidant and anti-helmintic activities [3][4][5][6][7][8][9][10][11]. Schiff base metal complexes have applications in the areas from material science to biological sciences.…”

Section: Introductionmentioning

confidence: 99%

Molecular Spectroscopy and Molecular Docking Studies on (E)-1-(4-Bromobenzylidene) Thiourea

Das

Bharanidharan

Dhandapani³

2018

JNDC

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The organic molecule (E)-1-(4-bromobenzylidene)thiourea (BBTU) have been synthesized and characterized using FT-IR and FT-Raman spectral studies. The quantum chemical calculations of BBTU have been studied using DFT/B3LYP/6-31G(d,p) level of theory. The stable conformer is identified by the potential energy surface scan. The complete vibrational assignments were performed on the basis of PED analysis with the help of SQM method. NBO analysis was carried out to explore the various conjucative/hyperconjucative interactions within the molecule and their second order stabilization energy. The NLO activity of BBTU is calculated and compared with the standard Urea molecule. The energies of the FMOs are used for the determination of global reactivity descriptors. The electrophilic and nucleophilic charge sites were identified by the molecular electrostatic potential mapped surface. The molecular docking of BBTU is carried out with the receptors of 3U2D and 1JIJ to screen the bacterial activity.

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“…Being structural surrogates of nucleotides, benzimidazole derivatives exhibited the potential to interact with proteins, enzymes and receptors. Substituted benzimidazoles were found to possess various biological activities such as antibacterial [3] , antiinflammatory [4] , antifungal [5] , antitubercular [6] , anticancer [7] , anticonvulsant and antidiabetic [8] . A number of 2-thio-1H-benzimidazole derivatives have been demonstrated to exhibit potent antiparasitic [9,10] activities.…”

Section: Research Papermentioning

confidence: 99%

Synthesis, Spectral Characterization and Antimicrobial Studies of New Hybrid Heterocyclic Compounds Bearing 1H-benzimidazol-2-yl Thiomethyl Motif

Deshp¹,

Chavan²,

Nagarale³

et al. 2017

pharmaceutical-sciences

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Deshpande, et al.: Compounds with 1H-benzimidazol-2-yl Thiomethyl MotifTo understand the biological importance of heterocyclic cores, novel 1H-benzimidazol-2-yl thiomethyl incorporated hybrid compounds, 2-(benzimidazol-2-ylthiomethyl)-5-aryl-1,3,4-oxadizoles and 1-(2-(1H-benzo[d]imidazol-2-ylthio)acetyl)pyridazine/phthalazinediones were designed using molecular hybridization technique, synthesized and characterized. The compounds were screened for in vitro antimicrobial activity using the serial dilution technique and were found to exhibit weak antitubercular activity, excellent to moderate antibacterial and better antifungal activities against some tested organisms in comparison to the standard drugs. Thus, some of the title compounds demonstrated antimicrobial activity.

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Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases

Cited by 295 publications

References 19 publications

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C₁₇H₁₂N₂O₃

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C₁₇H₁₂N₂O₃

Molecular Spectroscopy and Molecular Docking Studies on (E)-1-(4-Bromobenzylidene) Thiourea

Synthesis, Spectral Characterization and Antimicrobial Studies of New Hybrid Heterocyclic Compounds Bearing 1H-benzimidazol-2-yl Thiomethyl Motif

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Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases

Cited by 295 publications

References 19 publications

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C17H12N2O3

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C17H12N2O3

Molecular Spectroscopy and Molecular Docking Studies on (E)-1-(4-Bromobenzylidene) Thiourea

Synthesis, Spectral Characterization and Antimicrobial Studies of New Hybrid Heterocyclic Compounds Bearing 1H-benzimidazol-2-yl Thiomethyl Motif

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Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C₁₇H₁₂N₂O₃

Crystal structure of (E)-3-((naphthalen-1-ylimino)methyl)-4-nitrophenol, C₁₇H₁₂N₂O₃