Synthesis and water-swelling of thermo-responsive poly(ester urethane)s containing poly(ε-caprolactone), poly(ethylene glycol) and poly(propylene glycol)

Loh, Xian Jun; Sng, Kian Boon Colin; Li, Jun

doi:10.1016/j.biomaterials.2008.04.015

Cited by 158 publications

(128 citation statements)

References 36 publications

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“…30 PEG-PCL micelles have been widely used as drug-delivery carriers to improve the solubility of hydrophobic drugs. 17,31 In addition, PEI (Mw 1,800 Da) chains have been conjugated to classic PEG-PCL amphiphilic compounds to create superior cationic polymers due to their ability to develop molecular attraction forces via electrostatic interactions between the positively charged amino groups of PEI and the negatively charged sialic acid residues of mucin.…”

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confidence: 99%

Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration

Li¹,

Li²,

Zhou³

et al. 2015

IJN

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Purpose The cornea is a main barrier to drug penetration after topical application. The aim of this study was to evaluate the abilities of micelles generated from a positively charged triblock copolymer to penetrate the cornea after topical application. Methods The triblock copolymer poly(ethylene glycol)-poly(ε-caprolactone)- g -polyethyleneimine was synthesized, and the physicochemical properties of the self-assembled polymeric micelles were investigated, including hydrodynamic size, zeta potential, morphology, drug-loading content, drug-loading efficiency, and in vitro drug release. Using fluorescein diacetate as a model drug, the penetration capabilities of the polymeric micelles were monitored in vivo using a two-photon scanning fluorescence microscopy on murine corneas after topical application. Results The polymer was successfully synthesized and confirmed using nuclear magnetic resonance and Fourier transform infrared. The polymeric micelles had an average particle size of 28 nm, a zeta potential of approximately +12 mV, and a spherical morphology. The drug-loading efficiency and drug-loading content were 75.37% and 3.47%, respectively, which indicates that the polymeric micelles possess a high drug-loading capacity. The polymeric micelles also exhibited controlled-release behavior in vitro. Compared to the control, the positively charged polymeric micelles significantly penetrated through the cornea. Conclusion Positively charged micelles generated from a triblock copolymer are a promising vehicle for the topical delivery of hydrophobic agents in ocular applications.

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Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration

Li¹,

Li²,

Zhou³

et al. 2015

IJN

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“…2,12 Hence, the modulation of PU-based hydrogels with PEG improves the biocompatibility, and enables the adjustment of degradability and mechanical properties by varying the molecular mass or concentration of the PEG. 7,13 The ability to design PU-based hydrogels using a biodegradable and biocompatible polymer building block, either natural 2,12,14 or synthetic, 2,12,15,16 is an essential feature in tailoring their biodegradability and biocompatibility. Natural polymers are generally biocompatible, however their poor mechanical properties, fast degradation rates, poor reproducibility and potential immunogenicity restrict their use.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

et al. 2015

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Article:Frydrych, M., Román, S., Green, N.H. et al. (2 more authors) (2015) Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels. Polymer Chemistry, 6. 7974 -7987. ISSN 1759-9962 https://doi.org/10.1039/c5py01136a eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.

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“…From the environmental standpoint, it is also useful to develop biodegradable antibacterial polymers. With regards to biodegradable antibacterial compounds, there is also potential to use polyesters such as poly[(R)-3-hydroxybutyrate], [74][75][76][77][78][79][80][81][82][83] poly(lactic acid), 84,85 poly(e-caprolactone) [86][87][88] or even polycarbonates. 89,90 These polyesters have been extensively used for the development of biomaterials and future work can focus on these polymer backbones and their subsequent modi¯cations.…”

Section: Outlook and Perspectivesmentioning

confidence: 99%

Latest Advances in Antibacterial Materials

Loh

2017

J. Mol. Eng. Mater.

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This paper will update readers on the latest work in the area of antibacterial polymeric systems. There is extensive literature on existing systems. This complexity con¯nes us to the latest antibacterial materials which possess (1) responsive antibacterial activity on their own; (2) antibio¯lm formation and (3) formation of antibacterial polymeric¯lms. The objective of this review is to provide an overview of the antibacterial synthetic polymer¯eld. In this paper, I will analyze the early promise of this technology as well as highlight potential challenges that adopters could face. The primary focus will be the application of materials to the medical industry and to show how these materials can be tailored to create responsive, customized bactericidal materials.

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Synthesis and water-swelling of thermo-responsive poly(ester urethane)s containing poly(ε-caprolactone), poly(ethylene glycol) and poly(propylene glycol)

Cited by 158 publications

References 36 publications

Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration

Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration

Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

Latest Advances in Antibacterial Materials

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