Synthesis and tuberculostatic activity of 4-amino-3-acylvinylthio-1,2,4-triazoles

Glotova, T. E.; Нахманович, А. С.; Aleksandrova, A. E.; Shchegoleva, R. A.; Виноградова, Т И

doi:10.1007/bf00764620

Cited by 2 publications

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“…As a continuation of the previous efforts, N-Mannich bases of isatin and its derivatives with triazole moiety were designed since the compounds having triazole nuclei have been found to show a variety of chemotherapeutic properties like antibacterial [109,110], antifungal [111,112], antitubercular [113,114] and anti-HIV [115,116]. In this series, 1-piperidinomethyl, 5-bromo, 3-[3'-(4"-pyridyl)-5'mercapto-4'-(H)-1', 2', 4'-triazol-4'-yl] imino isatin compound showed greater antimicrobial potency with no anti-HIV activity [117].…”

Section: Isatinimino Compounds a Potential Lead For The Effective Trmentioning

confidence: 99%

Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS

Sriram

Yogeeswari²

2003

CMC

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HIV is the most significant risk factor for many opportunistic infections like fungal, tuberculosis, etc. The intense media coverage of AIDS puts the public on an emotional roller caster, and inflated promises are engendered by each success. For the moment drugs acting as both HIV-reverse transcriptase inhibitors along with antimicrobial properties are one of the brightest hope. The Non-nucleoside reverse transcriptase inhibitors (NNRTIs) appear ideally suited for further development in the chemoprophylaxis and therapy of HIV infections. In recent years, isatinimino compounds have been reported to exhibit broad-spectrum chemotherapeutic properties that include anti-HIV, antituberculous, antifungal and antibacterial activities. Hence these leads should be regarded as structural hits in the search for more potent antimicrobial compounds with broad-spectrum chemotherapeutic properties for the effective treatment of HIV / AIDS. This review focuses on the design of isatinimino compounds, which resemble the NNRTIs for the development of an ideal anti-HIV drug.

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Section: Isatinimino Compounds a Potential Lead For The Effective Trmentioning

confidence: 99%

Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS

Sriram

Yogeeswari²

2003

CMC

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“…4-Amino-l,2,4-triazoline-3-thiones XH react with propenones [141] and propynones [141][142][143][144] to give products of addition at the mercapto group, CLIV and CLV. The latter cyclize to 1,3,4-thiadiazepines CLVI on heating in DMF.…”

Section: Reactions With Derivatives Of Ethylene and Acetylenementioning

confidence: 99%

Synthesis and properties of N-aminoazolinethiones and N-aminoazinethiones 2. Reactions

Dyablo¹,

Пожарский²

1997

Chem Heterocycl Compd

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Literature data on the reactivity of ct-mercapto derivatives of N-aminoazoles and N-aminoazines are reviewed.Data on the methods of synthesis of N-aminoazolinethiones and N-aminoazinethiones were systematically discussed in the first part of this review [1]. The sequel contains information on the chemical properties of these compounds, particularly pertaining to all types of heterocyclization involving the amino and mercapto groups. ELIMINATION OF N-AMINO AND MERCAPTO GROUPSThe basic method for the elimination of N-amino groups in heterocyclic aminothiones is treatment with nitrous acid. It is suggested that during these reactions, which usually occur with good yield, an unstable N-nitrosoamine of type I is formed, which decomposes with the evolution of nitrous oxide [2]. For example, the 1-aminoimidazoline-2-thiones II were converted into imidazolinethiones III In a number of cases oxidation of the mercapto group accompanied elimination of the amino group on treatment with nitrous acid. For example, 4-amino-l,2,4-triazoline-3,5-dithione (IV) was converted to the disulfide V in 95% yield [9]. The formation of similar disulfides was also observed for 3-aminothiazoline-2-thiones [10-12], 4-amino-5-anilino-l,2,4-triazoline-3-thiones [13] Rostov State University, Rostov-on-Don 344090.

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Synthesis and tuberculostatic activity of 4-amino-3-acylvinylthio-1,2,4-triazoles

Cited by 2 publications

References 0 publications

Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS

Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS

Synthesis and properties of N-aminoazolinethiones and N-aminoazinethiones 2. Reactions

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