Secondary phosphine oxides reacted with 1-alkanoyl-2-phenylacetylenes in chemoselective fashion under mild conditions (20°C, THF) in the absence of a catalyst (diphenylphosphine oxide) or in the presence of potassium hydroxide [bis(2-phenylethyl)phosphine oxide] to give 1-alkyl-1-diphenyl(or 2-phenylethyl)-phosphoryl-3-phenylprop-2-yn-1-ols in up to 96% yield. The reaction of diphenylphosphine oxide with 1-alkanoyl-2-phenylacetylenes in the system KOH-THF (20°C) afforded not only adducts at the carbonyl group but also products of double α,β-addition at the triple bond, 2,3-bis(diphenylphosphoryl)-3-phenylpropan-1-ones.
Durch Reaktion der Acetylenketone (I), die über eine aktivierte Acetylenfunktion verfügen, mit Dithiobiuret im Molverhältnis 4:1 werden die Bis‐ketovinylsulfide (IIIa) bzw. (IIIb) als E/E‐,E/Z‐ und Z,Z‐Gemische erhalten.
The reaction of tri(2‐pyridyl)phosphine with electron‐deficient alkynes in water proceeds under mild conditions (40–45 °C, without catalyst, 4–5 h) with liberation of pyridine to give (E)‐pyridylvinylphosphine oxides in 45–56 % yields, the only exception being the reaction with cyanophenylacetylene, which affords the corresponding vinylphosphine oxide of Z‐configuration in 40 % yield. The reaction is likely triggered by the zwitterion, the adduct of tri(2‐pyridyl)phosphine to the electrophilic acetylenes, the carbanionic center of which is then neutralized by a proton from water. The intermediate phosphonium hydroxide finally decomposes to the product.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.