Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines – Their potential as adenosine receptor ligands

Sirisha, B.; Narsaiah, B.; Yakaiah, T.; Gayatri, G.; Sastry, G. Narahari; Mailavaram, Raghu Prasad; Akkinepally, Raghuram Rao

doi:10.1016/j.ejmech.2009.12.075

Cited by 30 publications

(13 citation statements)

References 25 publications

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“…This is attributed not only to the basic medium but also steric factors as the bulky phenyl group is in the 2 nd position [29]. Compound 4 was reacted further with hydrazine hydrate (80%) to obtain the corresponding 2-phenyl-4-quinazolinyloxyacetyl hydrazides 5 [30].…”

Section: Results and Discussion Chemistrymentioning

confidence: 99%

Synthesis, Antimicrobial Evaluation, and Docking Studies of Novel 4‐Substituted Quinazoline Derivatives as DNA‐Gyrase Inhibitors

Boyapati¹,

Kulandaivelu²,

Sangu³

et al. 2010

Archiv der Pharmazie

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Quinazoline derivatives are reported to have anti-inflammatory, analgesic, antibacterial, and anticancer activities. The incorporation of "OCH₂CONH₂" (oxymethylcarbamide) at 4th position of the quinazoline ring was found to influence the biological activities of the molecules. With this rationale, some new oxadiazolyl methyloxy quinazolines, pyrazolyl acetoxy methyl quinazolines, triazolylmethyloxy quinazolines were synthesized from anthranilic acid through quinazolyl oxyacetylhydrazide intermediates. All the compounds were characterized by IR, ¹H-NMR, EI-MS, and C, H, N analyses and evaluated for their antimicrobial activity. Docking studies on the DNA-gyrase enzyme (1KZN) show their role in the antimicrobial activity of the molecules and explain the higher potency of compounds 6a, 6b, 8a, 8b based on ReRanking scores and binding poses of the molecules.

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Section: Results and Discussion Chemistrymentioning

confidence: 99%

Synthesis, Antimicrobial Evaluation, and Docking Studies of Novel 4‐Substituted Quinazoline Derivatives as DNA‐Gyrase Inhibitors

Boyapati¹,

Kulandaivelu²,

Sangu³

et al. 2010

Archiv der Pharmazie

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“…Both of them are derived from ATP, which is a natural antagonist of P2Y 12 [5,19]. The antagonists with other scaffolds, such as piperazinyl-glutamate-pyrimidines [20], piperazinyl-glutamatepyridines [21], and thienopyrimidines [22], were also discovered [23] ( Fig. 1).…”

Section: Introductionmentioning

confidence: 97%

Molecular mechanism of action for reversible P2Y12 antagonists

Peng

Xiao

et al. 2011

Biophysical Chemistry

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“…The method of synthesis of 1,2,4‐triazolo[4,3‐a]pyridines is mainly from 2‐pyridyl hydrazine by cyclodehydration agents . On the basis of the importance and continuation of our efforts to synthesize potential molecules, we have developed a convenient method for the synthesis of novel 1,2,4‐triazolo[4,3‐a]pyridine derivatives, and are reporting here for the first time.…”

Section: Introductionmentioning

confidence: 99%

A Facile Approach for the Synthesis of Novel 1,2,4‐Triazolo[4,3‐a]Pyridine Derivatives in Single Step

Kumar

Kurumurthy

Veeraswamy

et al. 2014

Journal of Heterocyclic Chem

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Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines – Their potential as adenosine receptor ligands

Cited by 30 publications

References 25 publications

Synthesis, Antimicrobial Evaluation, and Docking Studies of Novel 4‐Substituted Quinazoline Derivatives as DNA‐Gyrase Inhibitors

Synthesis, Antimicrobial Evaluation, and Docking Studies of Novel 4‐Substituted Quinazoline Derivatives as DNA‐Gyrase Inhibitors

Molecular mechanism of action for reversible P2Y12 antagonists

A Facile Approach for the Synthesis of Novel 1,2,4‐Triazolo[4,3‐a]Pyridine Derivatives in Single Step

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