Synthesis and the antimicrobial activity of ethyl 5-methyl-2-(alkylthio)-4-oxo-3,4-dihydrothieno [2,3-d]pyrimidine-6-carboxylates

Novel One-Pot Synthesis of Methyl 4-Hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate: Synthetic and Crystallographic Studies

“…By analogy with N-nucleophiles [8][9][10][11][12][13][14][15][16][17][18], malonic ester as C-nucleophile reagent could also react with methyl 2-isothiocyanatobenzoate 12 in relatively mild condition, directly producing 4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate structure, which would be useful for development of new effective antibacterial drugs.…”

“…The interaction of the methyl 2-isothiocyanatobenzoate 12 with primary amines or hydrazine derivatives is a high-performance method for synthesis of 3-substituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines containing various substituents in 3 position of quinazoline ring (alkyl, aryl, hetaryl, etc.) in mild condition with high yields [8][9][10][11][12][13][14][15][16][17][18]. In continuation of these studies, we investigated the interaction of methyl 2-isothiocyanatobenzoate 12 with C-nucleophiles on the example of malonic ester.…”