Synthesis and Surface Engineering of Inorganic Nanomaterials Based on Microfluidic Technology

Abstract

The controlled synthesis and surface engineering of inorganic nanomaterials hold great promise for the design of functional nanoparticles for a variety of applications, such as drug delivery, bioimaging, biosensing, and catalysis. However, owing to the inadequate and unstable mass/heat transfer, conventional bulk synthesis methods often result in the poor uniformity of nanoparticles, in terms of microstructure, morphology, and physicochemical properties. Microfluidic technologies with advantageous features, such as precise fluid control and rapid microscale mixing, have gathered the widespread attention of the research community for the fabrication and engineering of nanomaterials, which effectively overcome the aforementioned shortcomings of conventional bench methods. This review summarizes the latest research progress in the microfluidic fabrication of different types of inorganic nanomaterials, including silica, metal, metal oxides, metal organic frameworks, and quantum dots. In addition, the surface modification strategies of nonporous and porous inorganic nanoparticles based on microfluidic method are also introduced. We also provide the readers with an insight on the red blocks and prospects of microfluidic approaches, for designing the next generation of inorganic nanomaterials.

Fabrication of aerosol-based nanoparticles and their applications in biomedical fields

“…In another study, iron oxide nanoparticles were obtained via flame pyrolysis of a Fe(NO 3 ) 3 ∙9H 2 O and FeC 6 H 5 O 7 ∙4H 2 O solution. The synthetic reaction conditions, such as the key precursor solution, solution amount, and reaction environment, were maintained to obtain nanoparticles with a precise particle size, structural phase, and texture (Shen et al 2020 ). Recently, the flame spray pyrolysis technique was modified using the SpraySyn nozzle.…”

Adsorptive Removal of Cd, Cu, Ni and Mn from Environmental Samples Using Fe3O4-Zro2@APS Nanocomposite: Kinetic and Equilibrium Isotherm Studies

“…These limitations have been solved by the surface modification using appropriate organic functional groups, leading to the formation of nanocomposites [ 23 , 25 , 29 ]. This is usually achieved by merging synthetic polymers on inorganic nanoparticles or by adding modified nanoparticles to polymer matrices [ 29 , 30 ]. These modifications have led to high adsorption affinity and enabled specific metal complexation [ 23 , 24 , 25 , 29 , 30 ].…”

“…This is usually achieved by merging synthetic polymers on inorganic nanoparticles or by adding modified nanoparticles to polymer matrices [ 29 , 30 ]. These modifications have led to high adsorption affinity and enabled specific metal complexation [ 23 , 24 , 25 , 29 , 30 ].…”

A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy

“…Also, an approach for octahedral nanoparticles and other morphologies such as truncated cubes, cuboctahedra, and truncated octahedra were reported to develop as the plane encompassing the x, y, and z direction is formed at different convective solvent flows and vertex truncation [12]. Furthermore, a bottom-up process of core-shell type Pt-Pd icosahedral nanoparticle formulation that implements multiphase (air/liquid) microfluidics employing sodium tetrachloropalladate (Na2PdCl4) and PVP dispersed diethylene glycol solution was reported [13]. Moreover, a method of creating concave polyhedral specifically tris-octahedral nanoparticles, was shown by adding a higher concentration of reductants (like halide anions), which tempered the formation of gold nanoparticles with desired morphology [14].…”