Synthesis and study of novel fulleropyrrolidines bearing biologically active 1,4-dihydropyridines

Infrared Irradiation Synthesis of Substituted 5‐Oxo‐1, 2, 3, 4, 5, 6, 7, 8‐octahydroquinoline Derivatives under Solvent‐free Conditions

“…IR spectra were recorded on Bio-Rad FTS-40 spectrometer (KBr). 1 HNMR spectra were measured on Bruker AVANCE 400(400 MHz) spectrometer in CDCl 3 using TMS as internal standard .The reaction was performed under W-10 IR lamp(with a nominal power of 500 W; Beijing Zhen-xing lab instrument Co., Ltd.).…”

“…For example, they have been used as effective calcium channel modulators for the treatment of cardiovascular disorders 1 . 4-Substituted 1, 4-dihydropyridines are analogues of NADH coenzymes and can be used as medicine 2 .…”

Nano aluminium nitride as a solid source of ammonia for the preparation of hantzsch 1,4-dihydropyridines and bis-(1,4-dihydropyridines) in water via one pot multicomponent reaction

“…[11][12][13] The classical method for the synthesis of these compounds is the Hantzsch reaction involving a multicomponent condensation of an aldehyde with a 1,3-dicarbonyl compound and NH 3 .…”

Lewis Acid‐Catalyzed Sequential Transformations: Straightforward Preparation of Functional Dihydropyridines

“…[1] Current literature reveals that 1,4-dihydropyridines exhibit neuroprotectant and platelet anti-aggregratory activity, and show efficient biological properties as cerebral anti-ischemic agents in the treatment of Alzheimers disease and as chemosensitizers in tumour therapy. [2][3][4][5] Dihydropyridines are usually subsequently oxidized to pyridines. [6] Many classical methods for the synthesis of symmetrical 1,4-dihydropyridines have been reported [7][8][9][10][11] based on conventional heating of a b-keto ester, an ammonium salt and an aldehyde in organic solvents, but most of these methods involve long reaction times, harsh reaction conditions and generally lead to low yields.…”

“…[6] Many classical methods for the synthesis of symmetrical 1,4-dihydropyridines have been reported [7][8][9][10][11] based on conventional heating of a b-keto ester, an ammonium salt and an aldehyde in organic solvents, but most of these methods involve long reaction times, harsh reaction conditions and generally lead to low yields. Therefore, it is necessary to develop more efficient and versatile methods for the preparation of 1,4-dihydropyridines and the progress in this field has been recently achieved by the use of promoters such as microwaves, [6b,12] TMSCl, [5] ionic liquids, [13,14] polymers [15,16] and YbA C H T U N G T R E N N U N G (OTf) 3 . [17] A synthesis of N-benzyl-1,4-dihydropyridines was also disclosed from 1-aza-1,3-butadiene via a Diels-Alder reaction.…”