Synthesis and study of a molecularly imprinted polymer for the specific extraction of indole alkaloids from Catharanthus roseus extracts

Lopez, Claire; Claude, Bérengère; Morin, Pascal; Max, Jean-Paul; Pena, R.; Ribet, Jean‐Paul

doi:10.1016/j.aca.2010.09.051

Cited by 45 publications

(18 citation statements)

References 25 publications

(27 reference statements)

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“…The chemical structures of the studied triazine compounds are illustrated in Figure 6. The imprinting factor expresses the ratio of specific-to-nonspecific binding for each compound (IF = Q MIP / Q NIP ) [34]. In each case, analyte uptake was normalized against the levels of MIP adsorbed and expressed as selectivity index (SI): SI = I(analyte)/I(template) [35].…”

Section: Resultsmentioning

confidence: 99%

Atrazine Molecular Imprinted Polymers: Comparative Analysis by Far-Infrared and Ultraviolet Induced Polymerization

Chen

Bai

Liu

et al. 2014

IJMS

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Atrazine molecular imprinted polymers (MIPs) were comparatively synthesized using identical polymer formulation by far-infrared (FIR) radiation and ultraviolet (UV)-induced polymerization, respectively. Equilibrium binding experiments were carried out with the prepared MIPs; the results showed that MIPuv possessed specific binding to atrazine compared with their MIPFIR radiation counterparts. Scatchard plot’s of both MIPs indicated that the affinities of the binding sites in MIPs are heterogeneous and can be approximated by two dissociation-constants corresponding to the high-and low-affinity binding sites. Moreover, several common pesticides including atrazine, cyromazine, metamitron, simazine, ametryn, terbutryn were tested to determine their specificity, similar imprinting factor (IF) and different selectivity index (SI) for both MIPs. Physical characterization of the polymers revealed that the different polymerization methods led to slight differences in polymer structures and performance by scanning electron microscope (SEM), Fourier transform infrared absorption (FT-IR), and mercury analyzer (MA). Finally, both MIPs were used as selective sorbents for solid phase extraction (SPE) of atrazine from lake water, followed by high performance liquid chromatography (HPLC) analysis. Compared with commercial C18 SPE sorbent (86.4%–94.8%), higher recoveries of atrazine in spiked lake water were obtained in the range of 90.1%–97.1% and 94.4%–101.9%, for both MIPs, respectively.

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Section: Resultsmentioning

confidence: 99%

Atrazine Molecular Imprinted Polymers: Comparative Analysis by Far-Infrared and Ultraviolet Induced Polymerization

Chen

Bai

Liu

et al. 2014

IJMS

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“…The sites can be classified in several families depending on their binding energy beside the template. Each family is characterized by its equilibrium dissociation constant (K d , mg L −1 ), as well as by its maximum adsorption capacity (Q max , mg g −1 ) [26]. In order to validate the Q max values of the MIP and further to understand its binding characteristic, Scatchard model was used.…”

Section: Resultsmentioning

confidence: 99%

Application of Molecularly Imprinted Polymers to Selective Removal of Clofibric Acid from Water

Dai

Zhang

et al. 2013

PLoS ONE

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A new molecularly imprinted polymer (MIP) adsorbent for clofibric acid (CA) was prepared by a non-covalent protocol. Characterization of the obtained MIP was achieved by scanning electron microscopy (SEM) and nitrogen sorption. Sorption experimental results showed that the MIP had excellent binding affinity for CA and the adsorption of CA by MIP was well described by pseudo-second-order model. Scatchard plot analysis revealed that two classes of binding sites were formed in the MIP with dissociation constants of 7.52±0.46 mg L−1 and 114±4.2 mg L−1, respectively. The selectivity of MIP demonstrated higher affinity for CA over competitive compound than that of non-imprinted polymers (NIP). The MIP synthesized was used to remove CA from spiked surface water and exhibited significant binding affinity towards CA in the presence of total dissolved solids (TDS). In addition, MIP reusability was demonstrated for at least 12 repeated cycles without significant loss in performance.

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“…Thus, optimization polymerization conditions suggested that 0.3 mmol of sulpiride, 1.2 mmol of ITA, 4.5 mmol of EGDMA, 60 mg of AIBN and 6 mL of methanol for a MIP formulation, corresponding to the molar ratio of 1:4:15 for template-sulpiride/monomer-ITA/crosslinker-EGDMA, achieving a best value of specific adsorption. Recent publications frequently used the molar ratio of 1:4 although monomer could be ranging from 1 to 10 times the template in mole [25,26,27,28,29,30,31,32,33,34,35]. …”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride

et al. 2017

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A novel molecular imprinting polymer (MIP) was prepared by bulk polymerization using sulpiride as the template molecule, itaconic acid (ITA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. The formation of the MIP was determined as the molar ratio of sulpiride-ITA-EGDMA of 1:4:15 by single-factor experiments. The MIP showed good adsorption property with imprinting factor α of 5.36 and maximum adsorption capacity of 61.13 μmol/g, and was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and surface area analysis. With the structural analogs (amisulpride, tiapride, lidocaine and cisapride) and small molecules containing a mono-functional group (p-toluenesulfonamide, formamide and 1-methylpyrrolidine) as substrates, static adsorption, kinetic adsorption, and rebinding experiments were also performed to investigate the selective adsorption ability, kinetic characteristic, and recognition mechanism of the MIP. A serial study suggested that the highly selective recognition ability of the MIP mainly depended on binding sites provided by N-functional groups of amide and amine. Moreover, the MIP as solid-phase extractant was successfully applied to extraction of sulpiride from the mixed solution (consisted of p-toluenesulfonamide, sulfamethoxazole, sulfanilamide, p-nitroaniline, acetanilide and trimethoprim) and serum sample, and extraction recoveries ranged from 81.57% to 86.63%. The tentative tests of drug release in stimulated intestinal fluid (pH 6.8) demonstrated that the tablet with the MIP–sulpiride could obviously inhibit sulpiride release rate. Thus, ITA-based MIP is an efficient and promising alternative to solid-phase adsorbent for extraction of sulpiride and removal of interferences in biosample analysis, and could be used as a potential carrier for controlled drug release.

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Synthesis and study of a molecularly imprinted polymer for the specific extraction of indole alkaloids from Catharanthus roseus extracts

Cited by 45 publications

References 25 publications

Atrazine Molecular Imprinted Polymers: Comparative Analysis by Far-Infrared and Ultraviolet Induced Polymerization

Atrazine Molecular Imprinted Polymers: Comparative Analysis by Far-Infrared and Ultraviolet Induced Polymerization

Application of Molecularly Imprinted Polymers to Selective Removal of Clofibric Acid from Water

Preparation, Characterization and Application of a Molecularly Imprinted Polymer for Selective Recognition of Sulpiride

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