Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives

Michael Cyclization of Polarized Systems: Synthesis and in vitro Anti-Diabetic Evaluation of Some Novel Pyrimidine, Pyridine, Pyrazole and Pyrazolo[3,4-b ]pyridine Derivatives

“…[20,21] Also, Pyrazoline derivatives widely occur in the environment, in the form of alkaloids, vitamins and pigments as constituents of plant and animal cell. Considerable attention has been carried out on the pyrazolines and substituted pyrazolines due to their inspiring biological activities such as antibacterial, antifungal, [22][23][24] antidepressant, [25][26][27][28] anticonvulsant, [29] and antitumor, [30] properties. The pyrazoline, a versatile moiety is present as the core constituent in a variety of leading drugs such as Sildenafil, Celebrex, and Rimonabant etc.…”

Synthesis of 1-phenyl-3-(4’-nitrophenyl)-5-(3’,4’-dimethoxy-6’-nitrophenyl)-2-pyrazoline and its antibacterial activity

“…Pyrazole and pyrazoline are important nitrogen containing 5-membered heterocyclic compound. Pyrazoline which is well known as pyrazole derivative or 4,5-dihydropyrazole is reported possess a broad spectrum of biological activities such as anticonvulsant [2], antimicrobial [1,3,8], antiamoebic [3], analgesic [1], anti-inflammmatory [1], antidepressant [4], anxiogenic [4], inhibitors of monoamine oxidase [4], fungisical [5], insecticidal [5], antitumor [6], and antinociceptive [7]. Therefore, the prevalence of pyrazole core in biologically active molecules has stimulated the need for elegant and efficient ways to make these heterocyclic lead.…”

Optimized Synthesis of Novel Pyrazole Based Thiazole Derivatives and their Antimicrobial Evaluation

“…Pyrazoles and its derivatives are well known for their biological and medicinal, applications, such as antimicrobial [1], antitumor [2], antileukemia [3], antidepressant [4], anticonvulsant [5], antifungal [6] and antitubercular [7]. Pyrazole analogoues can selectively inhibit (cyclooxygenase enzyme) COX-2 [8] they are also expressing anti-inflammatory, analgesic, antihypertensive, antipyretic, sedatives, and antidiabetic activities [9,10].…”