Synthesis and structure–activity relationships of novel pyrimido[1,2-b]indazoles as potential anticancer agents against A-549 cell lines

Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in mice

“…It is therefore important to determine these physicochemical properties associated with a drug, before synthetic work is undertaken. The estimated log P values (P is the partition coefficient of the molecule in the water/octanol system), which can be used as an indicator of passive diffusion across cell membranes and cellular uptake [58][59][60], were determined for all urea and thiourea derivatives and are presented in Table 1. The lipophilicity study showed that most of compounds possess optimum lipophilicities (log P 1.64-4.47) required for oral absorption and biomembrane penetration, even for BBB penetration according to Lipinski's drug-likeness 'rules of five' [61].…”

Synthesis, biological evaluation and molecular modeling of novel series of pyridine derivatives as anticancer, anti-inflammatory and analgesic agents

“…The lipophilicity of the compounds is well known to play an important role in the penetration of these compounds into cells. The partition coefficient Log P is a parameter which describes the manner in which a drug partitions between polar and non-polar phases, and it has been demonstrated to be an indispensable tool in predicting the transport and activity of drugs [54][55][56][57]. Assuming that the issue of penetration is even more crucial for compound's activity against cell, our results demonstrated that simply increasing the lipophilic character of compounds increased the activity, as shown with Log P values of the synthesized compounds (1.02-2.69).…”

Synthesis, Antimicrobial Evaluation, and Docking Studies of Novel 4‐Substituted Quinazoline Derivatives as DNA‐Gyrase Inhibitors

“…In continuation of our efforts to synthesize quinazoline derivatives [23][24][25], we report the synthesis of novel 2,6-substituted quinazoline derivatives with ''OCH 2 CONH 2 '' substitution at the 4 th position along with their antimicrobial activities. The possibility of an involvement of the DNA-gyrase enzyme in the activity of quinazolines was confirmed from docking studies.…”