Synthesis and Structural Characterization of (2,4-Diamino-5-(3′,4′,5′-Trimethoxybenzyl)Pyrimidine Copper (II)) Complex

Habib, Uzma; Badshah, Amin; Flörke, Ülrich; Qureshi, Rizwana Aleem; Mirza, Bushra; Nazar-ul-Islam,; Khan, Azeem

doi:10.1007/s10870-009-9545-9

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Cited by 6 publications

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“…Pyrimidines are known as suitable ligands for various metal salts, including zinc and copper . The biological activity of vitamin B 1 is related to complexation with zinc, the activity of trimethoprim is enhanced by complexation of copper . Therefore, we anticipated that an efficient method is necessary to separate the pyrimidine–metal complex in order to isolate product that complies to transition-metal specifications (<100 ppm).…”

Section: Resultsmentioning

confidence: 99%

Lewis Acid-Catalyzed Synthesis of 4-Aminopyrimidines: A Scalable Industrial Process

Létinois¹,

Schütz²,

Härter³

et al. 2013

Org. Process Res. Dev.

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Pyrimidine synthesis starting from acrylonitrile has been known since the 1960s. The new Lewis acid-catalyzed condensation reaction allows the synthesis of 4-aminopyrimidines starting from the easily accessible chemical acrylonitrile without the need for carcinogenic chemicals and costly derivatization in up to 90% yield. The method is versatile and applicable for industrial-scale synthesis of biologically relevant substances such as vitamin B1 and trimethoprim.

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Section: Resultsmentioning

confidence: 99%