Synthesis and spectroscopic characterisation of heptamethincyanine NIR dyes for their use in optochemical sensors

Ultrasensitive Near‐Infrared Raman Reporters for SERS‐Based In Vivo Cancer Detection

“…The amine group of 1 was Boc‐protected prior to the derivatization of the central chlorine atom with 80 structurally different primary amines including heterocyclic, alkyl, and aromatic groups (for structures, see Chart S1 in the Supporting Information). After acetylation, the compounds were treated with an optimized TFA/dichloromethane (1:9) solution that overcame the lability of the tricarbocyanine core in acidic conditions 22. The final coupling to a lipoic acid‐activated ester resin yielded 80 derivatives (CyNAMLA) with an average purity of 90 % (for data of HPLC‐determined purities, see Table S1 in the Supporting Information).…”

Functional Dyes, and Some Hi‐Tech Applications

“…Consequently, there has been an increase in the use of pH-sensitive fluorescent probes for intracellular studies [143]. In this interest, the use of cyanine dyes as fluorescent pH sensor has been growing [144][145][146].…”

Electrochemical Studies on Heptamethine Cyanine Dyes

“…This designed heptamethinecyanine compounds can be absorbed in near-infrared ranges as shown in this study [1][2][3][4][5][6][7][8] .…”

“…Recently, cyanines have received much attentions [1][2][3][4] to use because those compounds have wide application ranges such as photo-sensitizers, dye lasers, optical recordings and storage media. Herein, heptamethinecyanines being considered in this work are incorporating a cyclohexene ring in the polymethine chain.…”