Synthesis and spectral studies of novel nicotinonitrile-based fluorescent dyes

Synthesis of Bis‐Nicotinonitrile Derivatives and Investigations of Antimicrobial and Antibiofilm Activities

“…Elemental analyses were performed using a LECO CHNS 932 elemental analyzer (Michigan, ABD). 1 H-and 13 C-NMR spectra were recorded on an Agilent 600 MHz Premium COM-PACT NMR instrument (Agilent, Santa Clara, CA). The multiplicities of the signals in the 1 HNMR spectra are abbreviated by s (singlet), d (doublet), t (triplet), q (quartet), m (multiplet), br (broad), and combinations thereof.…”

“…In addition, nicotinonitrile derivatives show fluorescent properties because they consist a conjugated π‐bond system. For this reason, these compounds are among the important materials with application in electrochemical and optical studies [13] …”

“…For this reason, these compounds are among the important materials with application in electrochemical and optical studies. [13] Synthesis of nicotinonitrile derivatives are among the interesting and current topics in terms of their pharmacological activities and their use as intermediates in the synthesis of new and polyfunctional compounds. [14] There are different methods for the synthesis of nicotinonitrile derivatives in the literature, but one of the most common methods is the reactions of α,βunsaturated carbonyl compounds with malononitrile.…”

Simple and Efficient Synthesis of Highly Functional 2-Oxonicotino­nitriles from 2-Chloronicotinonitriles

“…Initially, we tested the known methods of substituting the halogen atom in polyfunctional pyridines 1 [39][40][41][42] using described above approaches as reflux in various acids (acetic, trifluoroacetic, hydrochloric) and reaction with alkaline solution, however, in all cases, the reaction either did not proceed, or difficult-to-separate mixtures were formed (Table 1). For example, the use of NaOH in H 2 O/EtOH medium for dicyanopyridines 1h,i leads to the formation of a mixture of hydrolysis products among which pyrrolo [3,4]pyridine-1,3-diones were identified.…”