Synthesis and spectral properties of 3-(2-aryl-5-methyl-1,3-oxazol- 4-yl)-2-(2,5-dimethylthiophen-3-yl)cyclopent-2-en-1-ones

Photocontrollable Modulation of Frontier Molecular Orbital Energy Levels of Cyclopentenone-Based Diarylethenes

“…The following features can be noted The experimental evaluation of ΔE HOMO−LUMO (Table 1) is in accordance with the results of UV/vis absorption spectroscopy. 22,23,34 The highest ΔE HOMO−LUMO (2.27 eV) with the most blue-shifted maximum (λ max = 505 nm) is observed for the closed-ring isomer of bisoxazolyl DAE 4 (Figure 3). The smallest energy gap (2.08 eV) with the most red-shifted maximum (λ max = 549 nm) was found for 3.…”

“…22,23,34 open-ring (283 nm ≤ λ max ≤ 329 nm) and photoinduced closed-ring forms (505 nm ≤ λ max ≤ 555 nm) as well as characteristic quantum yields of photocyclization (0.20 ≤ Φ ≤ 0.40) and cycloreversion (0.01 ≤ Φ ≤ 0.25). 22,23,34 Here, we attempted to study the effect of various combinations of electron-donating thiophene and electron-withdrawing oxazole moieties with a cyclopentenone bridge on the energy levels of the frontier molecular orbitals (pairs 1 and 2, Scheme 2). In addition, analogues of DAE 2 (pair 3) bearing strong electrondonating substituents at the β-position of the bridge were studied.…”

Practical Deoxygenation of Oxazole N-Oxides by PCl3/Collidine

“…[14a] Compounds 2a,i,j,m were described previously. [28] Compounds 3a,b were obtained in experiments with uncontrolled warming during fast addition of zinc to a solution of the corresponding oxazole N-oxides in AcOH.…”

“…Calcd for C 12 H 10 BrNO 2 : C, 51.45; H, 3.60; N, 5.00; Br, 28.53. Found: C, 52.32; H, 3.97; N, 4.71; Br, 28.42.1-[2-(4-Fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethanone (2i)White powder; yield: 0.136 g (78%); mp 85-87 °C (Lit [28]. mp 84-85°C ) 1 H NMR (300 MHz, CDCl 3 ): δ = 2.60 (s, 3 H, CH 3 ), 2.70 (s, 3 H, CH 3 ), 7.17 (t, J = 8.64 Hz, 2 H arom ), 8.05 (dd, J = 8.74, 5.34 Hz, 2 H arom ).…”

Синтез И Оценка Антипролиферативной Активности Арил(гетарил)производных Циклопентенона — Аналогов Комбретастатина a-4

“…Äèàðèëýòåí Va ñèíòåçèðîâàí ïî ìåòîäó [22] è åãî ñïåêòðàëüíûå ñâîéñòâà ñîîòâåòñòâóþò ëèòåðàòóðíûì äàííûì [28]. Äèàðèëýòåíû Vb [29] è Vc [30] ñèíòåçèðîâàíû ïî ðàíåå îïèñàííûì ìåòîäèêàì. Ýêñïåðèìåíòàëüíàÿ áèîëîãè÷åñêàÿ ÷àñòü ×åðåç 48 ÷ ïîñëå ïîñåâà êëåòîê â êóëüòóðû ââîäèëè èññëåäóåìûå âåùåñòâà â ðàçëè÷íûõ êîíöåíòðàöèÿõ è ÷åðåç 48 ÷ îïðåäåëÿëè âûaeèâàåìîñòü êëåòîê ñ ïîìîùüþ ïðèáîðà Multiwell plate (ELISA) reader.…”