Synthesis and self-association in aqueous media of poly(ethylene oxide)/poly(ethyl glycidyl carbamate) amphiphilic block copolymers

Dimitrov, Philip; Utrata-Wesołek, Alicja; Rangelov, Stanislav; Wałach, Wojciech; Trzebicka, Barbara; Dworak, Andrzej

doi:10.1016/j.polymer.2006.05.030

Cited by 47 publications

(50 citation statements)

References 34 publications

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“…The measured R h values indicated that the coreshell structures that were formed by the investigated copolymers were similar to those observed for other polyether diblock copolymers containing a PEO and a polyglycidol block modified by ethyl isocyanate (poly(ethylene oxide)-b-poly(ethyl glycidyl carbamate)) [54].…”

Section: Micellization Of Block Copolymerssupporting

confidence: 76%

“…1). The polymerization technique was found to yield welldefined products for which the composition could be controlled as described elsewhere [54,55].…”

Section: Synthesis Modification and Characterization Of Block Copolmentioning

confidence: 99%

“…It is frequently used as the hydrophilic block in micelle-forming copolymers. The most extensively studied cases include the micellization of PEO-containing copolymers with poly(propylene oxide) (PPO) [45][46][47][48][49], poly(butylenes oxide) (PBO) [50][51][52][53], and hydrophobically modified poly(2,3-epoxypropanol-1) (polyglycidol, PGl) [54][55][56].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polyether nanoparticles from covalently crosslinked copolymer micelles

Jamróz-Piegza

Wałach

Dworak

et al. 2008

Journal of Colloid and Interface Science

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Section: Micellization Of Block Copolymerssupporting

confidence: 76%

“…1). The polymerization technique was found to yield welldefined products for which the composition could be controlled as described elsewhere [54,55].…”

Section: Synthesis Modification and Characterization Of Block Copolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polyether nanoparticles from covalently crosslinked copolymer micelles

Jamróz-Piegza

Wałach

Dworak

et al. 2008

Journal of Colloid and Interface Science

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“…[12,[16][17][18][19][20] Out of the many polymers bearing ether or amide moieties that show LCST behavior, the most popular one is poly(N-isopropylacrylamide) (PNIPA), by virtue of the weak dependence of the transition temperature (cloud point) on concentration and molar mass, as well as of the convenient switching temperature around 30-35 8C. [21] The choice of an appropriate hydrophobic ''B'' block seems a priori nearly unlimited from the pool of water-insoluble polymers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Symmetrical Triblock Copolymers of Styrene and N‐isopropylacrylamide Using Bifunctional Bis(trithiocarbonate)s as RAFT Agents

Bivigou-Koumba

Kristen

Laschewsky

et al. 2009

Macro Chemistry & Physics

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Six new bifunctional bis(trithiocarbonate)s were explored as RAFT agents for synthesizing amphiphilic triblock copolymers ABA and BAB, with hydrophilic “A” blocks made from N‐isopropylacrylamide and hydrophobic “B” blocks made from styrene. Whereas the extension of poly(N‐isopropylacrylamide) by styrene was not effective, polystyrene macroRAFT agents provided the block copolymers efficiently. End group analysis by 1H NMR spectroscopy supported molar mass analysis and revealed an unexpected side reaction for certain bis(trithiocarbonate)s, namely a fragmentation to simple trithiocarbonates while extruding ethylenetrithiocarbonate. The amphiphilic block copolymers with short polystyrene blocks are directly soluble in water and self‐organize into thermoresponsive micellar aggregates.

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“…To obtain PG-b-PCL block copolymers, the ethoxyethyl groups were removed from PEEGE-b-PCL according to the method reported by Dimitrov et al [30] The certain amount of PEEGE-b-PCL was dissolved in acetone, and then oxalic acid aqueous solution was added. The reaction mixture was stirred at room temperature for 16 h and neutralized with Ca(OH) 2 .…”

Section: Synthesis Of Poly[glycidol-block-(e-caprolactone)] (Pgb-pcl)mentioning

confidence: 99%

The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐block‐(ε‐caprolactone)] Copolymers

Mao

Gan

2009

Macromolecular Bioscience

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An amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.

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Synthesis and self-association in aqueous media of poly(ethylene oxide)/poly(ethyl glycidyl carbamate) amphiphilic block copolymers

Cited by 47 publications

References 34 publications

Polyether nanoparticles from covalently crosslinked copolymer micelles

Polyether nanoparticles from covalently crosslinked copolymer micelles

Synthesis of Symmetrical Triblock Copolymers of Styrene and N‐isopropylacrylamide Using Bifunctional Bis(trithiocarbonate)s as RAFT Agents

The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol‐block‐(ε‐caprolactone)] Copolymers

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