Synthesis and self‐assembly of multiple‐responsive magnetic nanogels

Yao, Haiyang; Li, Xueting; Shi, Xiaodi; Qiu, Gao; Lu, Xihua

doi:10.1002/pat.4467

Cited by 8 publications

(8 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 The magnetic property of the material signifies its various potential applications such as in magnetic resonance imaging (MRI), 49b drug delivery, 49c magnetically targeted therapy of tumor, 46 and magnetic separation, 49a in addition to its applications as an NMR contrast agent. 51 2.4. Thermogravimetric Analysis (TGA).…”

Section: Resultsmentioning

confidence: 99%

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

View full text Add to dashboard Cite

Superparamagnetism has been widely used for many biomedical applications, such as early detection of inflammatory cancer and diabetes, magnetic resonance imaging (MRI), hyperthermia, etc., whereas incorporation of superparamagnetism in stimulus-responsive hydrogels has now gained substantial interest and attention for application in these fields. Recently, pH-responsive superparamagnetic hydrogels showing the potential use in disease diagnosis, biosensors, polymeric drug carriers, and implantable devices, have been developed based on the fact that pH is an important environmental factor in the body and some disease states manifest themselves by a change in the pH value. However, improvement in pH sensitivity of magnetic hydrogels is a dire need for their practical applications. In this study, we report the distinctly high pH sensitivity of new synthesized dual-responsive magnetic hydrogel nanocomposites, which was accomplished by copolymerization (free-radical polymerization) of two pH-sensitive monomers, acrylic acid (AA) and vinylsulfonic acid (VSA) with an optimum ratio, in the presence of presynthesized superparamagnetic iron oxide nanoparticles (Fe 3 O 4 (OH) x ). The monomers contain pH-sensitive functional groups (COO – and SO 3 – for AA and VSA, respectively), and they have also been widely used as biomaterials because of the good biocompatibility. The pH sensitivity of the superparamagnetic hydrogel, poly(acrylic acid- co -vinylsulfonic acid), PAAVSA/Fe 3 O 4 , was investigated by swelling studies at different pH values from pH 7 to 1.4. Distinct pH reversibility of the system was also demonstrated through swelling/deswelling analysis. Thermal stability, chemical configuration, magnetic response, and structural properties of the system have been explored by suitable characterization techniques. Furthermore, the study reveals a pH-responsive significant change in the overall morphology and packing fraction of iron oxide nanoparticles in PAAVSA/Fe 3 O 4 via energy-dispersive X-ray (EDX) elemental mapping with the field emission scanning electron microscopy (FESEM) study (for freeze-dried PAAVSA/Fe 3 O 4 , swelled at different pH values), implying a drastic change in susceptibility and induced saturation magnetization of the system. These important features could be easily utilized for the purpose of diagnosis using magnetic probe and/or impedance analysis techniques.

show abstract

Section: Resultsmentioning

confidence: 99%

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

2020

View full text Add to dashboard Cite

show abstract

“…These range from a simple mixture of MNPs and nanogel suspensions 20,32,37 to the in situ synthesis of nanogels in the presence of a solution of MNPs, 35,38,39 or vice versa by the in situ synthesis of MNPs in a nanogel dispersion. 40,41 However, the non-covalent incorporation methods have important drawbacks like the desorption of the MNPs or the aggregation of the particles inside the nanogels that affects both the magnetic properties of the composites and the drug loading capacity of the systems.…”

Section: Introductionmentioning

confidence: 99%

Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Based on the same strategy as discussed in the ‘ In situ formation of magnetic nanoparticles through the co‐precipitation of iron salts in the presence of preformed polymers’ section above, the MNPs are formed in situ within an existing polymer network (NG or MG), generally through the co‐precipitation of Fe 2+ and Fe 3+ ions in basic conditions 95–99 …”

Section: Stimuli‐responsive Magnetic Polymer Hybridsmentioning

confidence: 99%

Rational design of stimuli‐responsive magnetic polymer hybrid (nano)materials

Nguyen

Ménager

Rieger

et al. 2023

Polymer International

View full text Add to dashboard Cite

Combining organic and inorganic materials is a fascinating strategy to produce hybrid materials that combine the advantages of both polymeric and inorganic materials. Among the various types of organic–inorganic hybrids, stimuli‐responsive magnetic polymer hybrids (RMPHs) are particularly promising materials for a wide variety of applications. While the magnetic properties are generally provided by the presence of magnetic nanoparticles, such as iron oxide nanoparticles, the polymeric compound brings the stimuli‐responsiveness, e.g. responsiveness to pH, temperature, redox reaction or irradiation. Furthermore, as the chemical structure and architecture of the polymeric materials are diverse and easily tunable, stimuli‐RMPHs have found applications in various domains, including catalysis, biotechnology, (bio)imaging and cancer therapy. Given the importance of the hybrids' shape and morphology for the targeted application, this review presents the possible synthetic strategies to rationally design stimuli‐RMPHs of various morphologies ranging from nanometric core–shell structures to nanogels, microgels and membranes. © 2023 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.

show abstract

Synthesis and self‐assembly of multiple‐responsive magnetic nanogels

Cited by 8 publications

References 34 publications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Target-Specific Superparamagnetic Hydrogel with Excellent pH Sensitivity and Reversibility: A Promising Platform for Biomedical Applications

Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels

Rational design of stimuli‐responsive magnetic polymer hybrid (nano)materials

Contact Info

Product

Resources

About