Abstract:The combination of magnetic nanoparticles and thermoresponsive nanogels represents an appealing strategy for the development of theranostic probes. These hybrid nanocarriers present several advantages such as outstanding properties for guided...
“…Since the resulting nanogels showed good biocompatibility, the concept was expanded in a second study by using magnetic nanoparticles as crosslinkers (Figure 11). 145 In this case, the same tendency was observed for tuning the VPTT by the ratio between DEGMA and OEGMA. Due to the magnetic properties of the colloids, they show great potential for guided therapy applications, photothermal release, and magnetic resonance imaging.…”
Polymeric micro-and nanogels are defined by their water-swollen hydrophilic networks that can often impart outstanding biocompatibility and highcolloidal stability. Unfortunately, this highly hydrophilic nature limits their potential in areas where hydrophobic or amphiphilic interactions are required, for example, the delivery of hydrophobic cargoes or tailored interactions with amphipathic (bio-)surfaces. To overcome this limitation, amphiphilic microÀ/nanogels are emerging as new colloidal materials that combine properties from hydrogel networks with hydrophobic segments, known from solid hydrophobic polymer particles or micellar cores. The ability to accurately adjust the balance of hydrophobic and hydrophilic components in such amphiphilic colloidal systems enables new tailored properties. This opens up new applications ranging from the
“…Since the resulting nanogels showed good biocompatibility, the concept was expanded in a second study by using magnetic nanoparticles as crosslinkers (Figure 11). 145 In this case, the same tendency was observed for tuning the VPTT by the ratio between DEGMA and OEGMA. Due to the magnetic properties of the colloids, they show great potential for guided therapy applications, photothermal release, and magnetic resonance imaging.…”
Polymeric micro-and nanogels are defined by their water-swollen hydrophilic networks that can often impart outstanding biocompatibility and highcolloidal stability. Unfortunately, this highly hydrophilic nature limits their potential in areas where hydrophobic or amphiphilic interactions are required, for example, the delivery of hydrophobic cargoes or tailored interactions with amphipathic (bio-)surfaces. To overcome this limitation, amphiphilic microÀ/nanogels are emerging as new colloidal materials that combine properties from hydrogel networks with hydrophobic segments, known from solid hydrophobic polymer particles or micellar cores. The ability to accurately adjust the balance of hydrophobic and hydrophilic components in such amphiphilic colloidal systems enables new tailored properties. This opens up new applications ranging from the
“…The photothermal conversion efficiency (PTCE) was calculated using the heating profiles of MPNC1, MPNC2, AgMNCs, and MNCs (all samples in a concentration of 0.125 mg/mL; Figure d–e). Notably, for these experiments, we had decided to use a 785 nm fix wavelength laser despite not being in the absorption maxima of the MPNCs for several reasons: (a) it is a more bioapplicable wavelength since it is better fitting in the biological NIR window, − (b) it is extensively used for both gold- and iron-based nanoparticles and therefore gives us a better comparison, − and (c) it is the closest wavelength to the NIR window where we can observe a contribution from the silver, gold, and anisotropic gold nanoparticles in the UV absorption (Figure c). As predicted by the UV–vis spectrum traces, AgMNCs significantly improved the PTCE of the MNCs from 18 to 27.9% due to the contribution of the silver atoms to the plasmonic band.…”
Magnetoplasmonic nanomaterials, which combine light and magnetic field responsiveness in an advantageous manner, are attractive candidates for bio-nanoapplications. However, the synthetic access to such hybrid particles has been limited by the incompatibility of the iron-and gold-based lattices. In this work, we provide the first insights into a new synthetic strategy for developing magnetoplasmonic anisotropic nanocomposites with prominent phototransducing properties. In our approach, magnetic nanocubes based on an alloy of iron oxide, zinc, and silver were constructed. In a key second stage, the galvanic replacement of silver with gold atoms yielded satellite-like magnetoplasmonic anisotropic structures. Superior magnetic and photoconverting properties were observed for the novel magnetoplasmonic nanocomposites when compared with the pure parent structures. Moreover, the synergy between the magnetic and optical stimuli was examined, showing shape-dependent contributions in the magnetization experiments. More importantly, an excellent cell ablation capability upon laser irradiation was observed for the magnetoplasmonic nanocomposites compared to the pure magnetic or plasmonic controls. Further demonstration of these novel theragnostic agents as MRI contrast agents is also reported even during the light-irradiation event. Thus, the described particles showed promising properties for bioapplications emerging from the novel synthetic methodology.
“…Ultrasonication-assisted free radical precipitation/dispersion polymerization was employed as the synthetic procedure. As indicated in a previous work, in the presence of inorganic NPs, the ultrasonication strategy should guarantee their colloidal stability during polymerization [ 42 ]. Therefore, inorganic cores are expected to be homogeneously distributed inside the polymeric network, avoiding particle aggregation, and maximizing the available surface for the polymeric covering.…”
Section: Resultsmentioning
confidence: 99%
“…Our previous studies performed with PNGs and magnetic NGs, demonstrated that the molar ratio of OEG monomers: DEGMA:OEGMA 80:20 allows to obtain appropriate LSCT for biomedical applications [ 31 , 34 , 42 ]. Therefore, in the present work, this condition was explored with the inorganic MSNs.…”
Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic effects. In this work, hybrid nanogels based on mesoporous silica nanoparticles, oligo (ethylene glycol) methacrylates, and acidic moieties were developed employing ultrasound-assisted free radical precipitation/dispersion polymerization. Chemical structure was characterized by infrared spectroscopy and nuclear magnetic resonance. Hydrodynamic diameters at different temperatures were determined by dynamic light scattering, and cloud point temperatures were determined by turbidimetry. Cell viability in fibroblast (NIH 3T3) and human prostate cancer (LNCaP) cell lines were studied by a standard colorimetric assay. The synthetic approach allows covalent bonding between the organic and inorganic components. The composition of the polymeric structure of hybrid nanogels was optimized to incorporate high percentages of acidic co-monomer, maintaining homogeneous nanosized distribution, achieving appropriate volume phase transition temperature values for biomedical applications, and remarkable pH response. The cytotoxicity assays show that cell viability was above 80% even at the highest nanogel concentration. Finally, we demonstrated the successful cell inhibition when they were treated with camptothecin-loaded hybrid nanogels.
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